"PKD2" Related Products


Recombinant Human PKD2

Cat.No. : PKD2-30689TH
Product Overview : Recombinant fragment of Human Polycystin 2 with N terminal proprietary tag; predicted MWt: 36.63 kDa including the tag.
Description : This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the polycystin family.Contains 1 EF-hand domain.
Gene Name : PKD2 polycystic kidney disease 2 (autosomal dominant) [ Homo sapiens ]
Official Symbol : PKD2
Synonyms : PKD2; polycystic kidney disease 2 (autosomal dominant); polycystin-2; Pc 2; PC2; PKD4; transient receptor potential cation channel; subfamily P; member 2; TRPP2;
Gene ID : 5311
mRNA Refseq : NM_000297
Protein Refseq : NP_000288
MIM : 173910
Uniprot ID : Q13563
Chromosome Location : 4q22.1
Function : ATPase binding; calcium ion binding; channel activity; cytoskeletal protein binding; ion channel activity;

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