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Native Human PLAT

Cat.No.: PLAT-30946TH
Product Overview: Native Human TPA Tissue Plasminogen Activator depleted plasma.
Description: This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Source: Native
Tissue specificity: Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: Sodium citrate
Storage: Store at -70°C
Sequence Similarities: Belongs to the peptidase S1 family.Contains 1 EGF-like domain.Contains 1 fibronectin type-I domain.Contains 2 kringle domains.Contains 1 peptidase S1 domain.
Gene Name: PLAT plasminogen activator, tissue [ Homo sapiens ]
Official Symbol: PLAT
Synonyms: PLAT; plasminogen activator, tissue; tissue-type plasminogen activator;
Gene ID: 5327
mRNA Refseq: NM_000930
Protein Refseq: NP_000921
MIM: 173370
Uniprot ID: P00750
Chromosome Location: 8p11.21
Pathway: Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Dissolution of Fibrin Clot, organism-specific biosystem;
Function: peptidase activity; protein binding; serine-type endopeptidase activity; serine-type endopeptidase activity;

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