Recombinant Human DDR1, GST-tagged
Cat.No. : | DDR1-509H |
Product Overview : | Recombinant Human DDR1, (amino acids 444 – end) with N-terminal GST tag expressed inBaculovirus infected Sf9 cellexpression system. MW= 76 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | DDR1-509H |
Description : | Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. |
Source : | Baculovirus infected Sf9 cell. |
Purity : | >80%. |
Application : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Formulated In : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 50% glycerol and 3mM DTT. |
Stability : | >12 months at –80°C. |
Gene Name : | DDR1 discoidin domain receptor tyrosine kinase 1 [ Homo sapiens ] |
Synonyms : | DDR1; discoidin domain receptor tyrosine kinase 1; DAAP-278B20.1; CAK; CD167; DDR; EDDR1; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE; OTTHUMP00000029344; OTTHUMP00000029345; OTTHUMP00000029346; OTTHUMP00000029347; PTK3A protein tyrosine kinase 3A; cell adhesion kinase; discoidin domain receptor family, member 1; discoidin receptor tyrosine kinase; epithelial discoidin domain receptor 1; mammarian carcinoma kinase 10; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase, receptor, type 4; EC 2.7.10.1 |
Gene ID : | 780 |
mRNA Refseq : | NM_001954 |
Protein Refseq : | NP_001945 |
MIM : | 600408 |
UniProt ID : | Q08345 |
Chromosome Location : | 6p21.3 |
Function : | ATP binding; nucleotide binding; protein binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity |
Products Types
◆ Recombinant Protein | ||
DDR1-1034R | Recombinant Rhesus Macaque DDR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
DDR1-2453H | Recombinant Human DDR1 Protein | +Inquiry |
DDR1-212H | Recombinant Human DDR1 Protein, MYC/DDK-tagged | +Inquiry |
Ddr1-1151M | Recombinant Mouse Ddr1 Protein(Asp22-Ala415), His-tagged | +Inquiry |
DDR1-7297H | Active Recombinant Human DDR1 protein(Arg444-Val913), His&GST-tagged | +Inquiry |
◆ Lysates | ||
DDR1-1709MCL | Recombinant Mouse DDR1 cell lysate | +Inquiry |
DDR1-401MCL | Recombinant Mouse DDR1 cell lysate | +Inquiry |
DDR1-2534HCL | Recombinant Human DDR1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1579 | DDR1 Functional Assay Kit | +Inquiry |
Kit-1560 | U2OS DDR1 Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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