Recombinant Human PPM1F

• Cat.No.: PPM1F-31046TH
• Product Overview: Recombinant full-length human PPM1F with an N-terminal tag, 74kDa.

Specification

• Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
• Source: E. coli
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F [ Homo sapiens ]
• Official Symbol: PPM1F
• Synonyms: PPM1F; protein phosphatase, Mg2+/Mn2+ dependent, 1F; protein phosphatase 1F (PP2C domain containing); protein phosphatase 1F; Ca(2+)/calmodulin dependent protein kinase phosphatase; CAMKP; CaMKPase; FEM 2; KIAA0015; partner of PIX 2; POPX2
• Gene ID: 9647
• mRNA Refseq: NM_014634
• Protein Refseq: NP_055449
• Uniprot ID: P49593
• Chromosome Location: 22q11.22
• Function: hydrolase activity; metal ion binding; protein serine/threonine phosphatase activity