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| Cat.No.: | PRDX4-30466TH |
| Product Overview: | Recombinant full length Human Peroxiredoxin 4 with N terminal His tag; 255 amino acids with tag, MWt 28.8 kDa. |
| Description: | The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. |
| Conjugation: | HIS |
| Source: | E. coli |
| Biological activity: | Specific activity: approximately 230-310 pmole/min/μg.Enzymatic activity was confirmed by measuring the remaining peroxide after incubation of PRDX4 and peroxide for 20 min at room temperature. Specific activity is defined as the amount of hydroperoxide t |
| Form: | Liquid |
| Purity: | >90% by SDS-PAGE |
| Storage buffer: | Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, pH 8.0 |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
| Sequence Similarities: | Belongs to the ahpC/TSA family.Contains 1 thioredoxin domain. |
| Gene Name: | PRDX4 peroxiredoxin 4 [ Homo sapiens ] |
| Official Symbol: | PRDX4 |
| Synonyms: | PRDX4; peroxiredoxin 4; peroxiredoxin-4; AOE37 2; |
| Gene ID: | 10549 |
| mRNA Refseq: | NM_006406 |
| Protein Refseq: | NP_006397 |
| MIM: | 606506 |
| Uniprot ID: | Q13162 |
| Chromosome Location: | X |
| Pathway: | Selenium Pathway, organism-specific biosystem; |
| Function: | oxidoreductase activity; thioredoxin peroxidase activity; |
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