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Recombinant Human PRDX4, His-tagged

Cat.No. : PRDX4-30466TH
Product Overview : Recombinant full length Human Peroxiredoxin 4 with N terminal His tag; 255 amino acids with tag, MWt 28.8 kDa.
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Description : The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.
Conjugation : HIS
Source : E. coli
Biological activity : Specific activity: approximately 230-310 pmole/min/μg.Enzymatic activity was confirmed by measuring the remaining peroxide after incubation of PRDX4 and peroxide for 20 min at room temperature. Specific activity is defined as the amount of hydroperoxide t
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the ahpC/TSA family.Contains 1 thioredoxin domain.
Gene Name : PRDX4 peroxiredoxin 4 [ Homo sapiens ]
Official Symbol : PRDX4
Synonyms : PRDX4; peroxiredoxin 4; peroxiredoxin-4; AOE37 2;
Gene ID : 10549
mRNA Refseq : NM_006406
Protein Refseq : NP_006397
MIM : 606506
Uniprot ID : Q13162
Chromosome Location : X
Pathway : Selenium Pathway, organism-specific biosystem;
Function : oxidoreductase activity; thioredoxin peroxidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary biological role of PRDX4 in cells? 05/09/2022

PRDX4 acts as a peroxidase, reducing peroxides to protect cells from oxidative stress.

What role does PRDX4 play in protein folding and quality control? 08/15/2020

It assists in protein folding and prevents the aggregation of misfolded proteins.

In which cellular compartments is PRDX4 primarily located? 07/14/2020

PRDX4 is primarily located in the endoplasmic reticulum and secreted extracellularly.

Are there potential therapeutic applications targeting PRDX4? 06/15/2020

Therapeutic applications may involve modulating PRDX4 activity to mitigate oxidative stress-related diseases.

How does PRDX4 contribute to the cellular antioxidant defense system? 10/18/2019

It reduces hydrogen peroxide and lipid peroxides, contributing to the antioxidant defense.

How is the activity of PRDX4 regulated within cells? 01/01/2019

Cellular redox status and covalent modifications regulate PRDX4 activity.

What happens when there is dysregulation or deficiency of PRDX4? 10/13/2018

PRDX4 deficiency can lead to increased oxidative stress and damage, affecting cellular functions.

Customer Reviews (3)

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Reviews
12/07/2021

    Delivery on time, perfect.

    01/19/2021

      Very effective protein product.

      10/24/2020

        High-quality, great for research.

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