Recombinant Mouse Fas (TNF Receptor Superfamily Member 6)

• Cat.No.: Fas-1735M

Specification

• Cat. No.: Fas-1735M
• Description: Fas forms the death inducing signalling complex (DISC) upon ligand binding. Membrane-anchored Fas ligand trimer on the surface of an adjacent cell causes trimerization of Fas receptor. This event is also mimicked by binding of an agonistic Fas antibody, though some evidence suggests that the apoptotic signal induced by the antibody is unreliable in the study of Fas signaling. To this end, several clever ways of trimerizing the antibody for in vitro research have been employed.
• Molecular Weight: The predicted molecular weight of Recombinant Mouse Fas is Mr 46 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55 kDa.
• Source: Sf 21 Insect Cells.
• State Of Matter: Lyophilized.
• Purity: >97% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: Fas Fas (TNF receptor superfamily member 6) [ Mus musculus ]
• Synonyms: Fas; Fas (TNF receptor superfamily member 6); lpr; APT1; CD95; APO-1; TNFR6; Tnfrsf6; AI196731; Fas antigen; lymphoproliferation; tumor necrosis factor receptor superfamily, member 6
• Gene ID: 14102
• mRNA Refseq: NM_001146708
• Protein Refseq: NP_001140180
• UniProt ID: P25446
• Chromosome Location: 19 C1; 19 23.0 cM
• Pathway: Allograft rejection; Alzheimer"s disease; Apoptosis; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Graft-versus-host disease; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Pathways in cancer; ype I diabetes mellitus; p53 signaling pathway
• Function: protein binding; receptor activity; transmembrane receptor activity