||Recombinant full length COX2 / Cyclooxygenase 2 protein (Human), a homodimer (70-74 kDa/subunit), contains a six histidine tag near the N-terminus.Isolated from a Baculovirus overexpression system in Sf 21 cells.
||Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
||Specific Activity: minimum 8,000 units per mg protein
||Preservative: 300μM diethyldithio-carbamate (DDC)Constituents: 0.1% Tween 20, 80mM Tris HCl, pH 8Note: If this preservative (DDC) is undesirable, it can be removed by standard desalting procedures, but the enzyme is unstable in the absence of the preserva
||Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
||Belongs to the prostaglandin G/H synthase family.Contains 1 EGF-like domain.