Recombinant Human PXN

• Cat.No.: PXN-29060TH
• Product Overview: Recombinant fragment of Human Paxillin (amino acids 356-558) withproprietary tag; 203aa (without tag), 48kDa.

Specification

• Description: This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445).
• Protein length: 203 amino acids
• Molecular Weight: 48.000kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Storage buffer: pH: 7.50Constituents:Tris acetate, 20% Glycerol, 0.03% EDTA
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the paxillin family.Contains 4 LIM zinc-binding domains.

Gene Information

• Gene Name: PXN paxillin [ Homo sapiens ]
• Official Symbol: PXN
• Synonyms: PXN; paxillin
• Gene ID: 5829
• mRNA Refseq: NM_001080855
• Protein Refseq: NP_001074324
• MIM: 602505
• Uniprot ID: P49023
• Chromosome Location: 12q24
• Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem
• Function: beta-catenin binding; metal ion binding; protein binding; vinculin binding; zinc ion binding