Recombinant Human PYGB

• Cat.No.: PYGB-26787TH
• Product Overview: Recombinant Full Length human GPBB; a single, non-glycosylated, polypeptide chain of 842 amino acids, 97 kDa.

Specification

• Description: The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.
• Source: E. coli
• Form: Liquid
• Purity: 70 - 90% by HPLC
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the glycogen phosphorylase family.

Gene Information

• Gene Name: PYGB phosphorylase, glycogen; brain [ Homo sapiens ]
• Official Symbol: PYGB
• Synonyms: PYGB; phosphorylase, glycogen; brain; glycogen phosphorylase, brain form
• Gene ID: 5834
• mRNA Refseq: NM_002862
• Protein Refseq: NP_002853
• MIM: 138550
• Uniprot ID: P11216
• Chromosome Location: 20
• Pathway: Glucose metabolism, organism-specific biosystem; Glycogen Metabolism, organism-specific biosystem; Glycogen breakdown (glycogenolysis), organism-specific biosystem; Insulin signaling pathway, organism-specific biosystem; Insulin signaling pathway, conserved biosystem
• Function: drug binding; glycogen phosphorylase activity; protein homodimerization activity; pyridoxal phosphate binding; sugar binding