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Recombinant Human PYGB

Cat.No.: PYGB-26787TH
Product Overview: Recombinant Full Length human GPBB; a single, non-glycosylated, polypeptide chain of 842 amino acids, 97 kDa.
Description: The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.
Source: E. coli
Form: Liquid
Purity: 70 - 90% by HPLC
Storage buffer: Preservative: NoneConstituents: 50% Glycerol
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Belongs to the glycogen phosphorylase family.
Gene Name: PYGB phosphorylase, glycogen; brain [ Homo sapiens ]
Official Symbol: PYGB
Synonyms: PYGB; phosphorylase, glycogen; brain; glycogen phosphorylase, brain form;
Gene ID: 5834
mRNA Refseq: NM_002862
Protein Refseq: NP_002853
MIM: 138550
Uniprot ID: P11216
Chromosome Location: 20
Pathway: Glucose metabolism, organism-specific biosystem; Glycogen Metabolism, organism-specific biosystem; Glycogen breakdown (glycogenolysis), organism-specific biosystem; Insulin signaling pathway, organism-specific biosystem; Insulin signaling pathway, conserved biosystem;
Function: drug binding; glycogen phosphorylase activity; protein homodimerization activity; pyridoxal phosphate binding; sugar binding;

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