"QPRT" Related Products

Recombinant Human QPRT, His-tagged

Cat.No.: QPRT-30232TH
Product Overview: Recombinant full length Human QPRT with a N terminal His tag; 317aa inclusive of tag, 32.9 kDa.
Description: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimers disease, and Huntingtons disease.
Protein length: 297 amino acids
Conjugation: HIS
Molecular Weight: 32.900kDa inclusive of tags
Source: E. coli
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: 0% NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH
Sequence Similarities: Belongs to the nadC/modD family.
Gene Name: QPRT quinolinate phosphoribosyltransferase [ Homo sapiens ]
Official Symbol: QPRT
Synonyms: QPRT; quinolinate phosphoribosyltransferase; nicotinate-nucleotide pyrophosphorylase [carboxylating]; nicotinate nucleotide pyrophosphorylase (carboxylating); QPRTase;
Gene ID: 23475
mRNA Refseq: NM_014298
Protein Refseq: NP_055113
MIM: 606248
Uniprot ID: Q15274
Chromosome Location: 16p11.2
Pathway: Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; Nicotinate and nicotinamide metabolism, organism-specific biosystem;
Function: nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein homodimerization activity;

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