Recombinant Human Glial Cell Derived Neurotrophic Factor GDNF-338H

Recombinant Human Glial Cell Derived Neurotrophic Factor


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Recombinant Human Glial Cell Derived Neurotrophic Factor

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Cat. No. : GDNF-338H
Description : Glial cell derived neurotrophic factor, also known as GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. GDNF potently promotes the survival of many types of neurons, most prominently, dopaminergic and motorneurons. GDNF regulates kidney development and spermatogenesis, and it affects alcohol consumption.
Source : NSO cells.
Molecular Weight : Mature human GDNF is a disulfide-linked homodimer and is predicted to contain two 134 amino acid residue peptides with a molecular mass of approximately 15 kDa.
State Of Matter : Lyophilized.
Purity : >97% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Biological Activity : The biological activity of Human GDNF was determined by its ability to support the survival and stimulate neurite outgrowth of cultured embryonic chick dorsal root ganglia neurons. The expected ED50 for this effect is typically 1 - 3 ng/mL.
Storage : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : GDNF glial cell derived neurotrophic factor [ Homo sapiens ]
Synonyms : GDNF; glial cell derived neurotrophic factor; ATF1; ATF2; HFB1-GDNF; Glial cell line-derived neurotrophic factor; Astrocyte-derived trophic factor; ATF; hGDNF; astrocyte-derived trophic factor; glial cell line derived neurotrophic factor; glial derived neurotrophic factor
Gene ID : 2668
mRNA Refseq : NM_000514
Protein Refseq : NP_000505
MIM : 600837
UniProt ID : P39905
Chromosome Location : 5p13.1-p12
Pathway : Axon guidance
Function : growth factor activity; protein homodimerization activity

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