GDNF

  • Official Full Name

    glial cell derived neurotrophic factor

  • Overview

    This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010]
  • Synonyms

    GDNF; glial cell derived neurotrophic factor; ATF1; ATF2; HSCR3; HFB1-GDNF; glial cell line-derived neurotrophic factor; ATF; astrocyte-derived trophic factor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Human
  • Mouse
  • Rat
  • Barley Grain
  • CHO
  • CHO-K1
  • E. coli
  • E.coli
  • HEK293
  • Hordeum Vulgare
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Sf21 Insect Cell
  • Wheat Germ
  • C
  • His
  • Fc|His
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|S
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GDNF-22H Active Recombinant Human GDNF, His-tagged Barley Grain His
Human GDNF-985H Active Recombinant Human GDNF CHO N/A
Human GDNF-8858H Active Recombinant Human GDNF,His-tagged Hordeum Vulgare N/A
Human GDNF-01HG Active GMP Recombinant Human GDNF Protein CHO-K1
Human GDNF-26274TH Recombinant Human GDNF E.coli N/A
Human GDNF-778H Recombinant Human GDNF protein, His-tagged E.coli His
Human GDNF-15H Recombinant Human GDNF Protein, His/S-tagged E.coli His/S
Human GDNF-7292H Active Recombinant Human GDNF protein(Arg83-Ile185) HEK293 N/A
Human GDNF-7293H Recombinant Human GDNF protein, Fc/His-tagged HEK293 Fc/His
Human GDNF-338H Recombinant Human Glial Cell Derived Neurotrophic Factor Mammalian cells N/A
Human GDNF-708H Recombinant Human GDNF Protein CHO N/A
Human GDNF-637H Recombinant Human GDNF protein E.coli N/A
Human GDNF-1549HCL Recombinant Human GDNF cell lysate Human Cell N/A
Human GDNF-06HG Active Recombinant Human GDNF Protein (Arg109-Ile211), GMP Grade NS0
Human GDNF-34H Human Glial cell line-derived neurotrophic factor Reference standard N/A
Human GDNF-5248HF Recombinant Full Length Human GDNF Protein, GST-tagged In Vitro Cell Free System GST
Human GDNF-133HG Active GMP Recombinant Human GDNF Protein Mammalian cells N/A
Human GDNF-4414H Recombinant Human GDNF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GDNF-054H Active Recombinant Human GDNF Protein E. coli
Human GDNF-150H Recombinant Human GDNF Protein E.coli
Human GDNF-4835H Recombinant Human GDNF Protein, GST-tagged Wheat Germ GST
Human GDNF-4414H-B Recombinant Human GDNF Protein Pre-coupled Magnetic Beads HEK293
Human GDNF-108H Recombinant Active Human GDNF Protein, His-tagged(C-ter) E.coli His(C-ter)
Human GDNF-279G Active Recombinant Human GDNF Protein CHO
Human GDNF-2955H Recombinant Human GDNF protein, His-SUMO-tagged E.coli His-SUMO
Human GDNF-2435H Recombinant Human GDNF Protein (Ser78-Ile211), C-His tagged E.coli C-His
Human GDNF-01H Recombinant Human GDNF Protein, His-tagged Insect Cell His
Human GDNF-2436H Recombinant Human GDNF Protein (Ser78-Gly107), N-His tagged E.coli N-His
Human GDNF-18H Recombinant Human GDNF Protein E.coli
Human GDNF-109H Active Recombinant Human GDNF Protein E.coli
Human GDNF-2437H Recombinant Human GDNF Protein (Ser78-Gly107), N-His and N-SUMO tagged E.coli N-His and N-SUMO
Human GDNF-120H Active Recombinant Human GDNF Protein (Ser78-Ile211), C-His tagged, Animal-free, Carrier-free E.coli C-His
Mouse GDNF-6293M Recombinant Mouse GDNF Protein Mammalian Cell His
Mouse Gdnf-16M Recombinant Mouse GDNF Protein, His/S-tagged E.coli His/S
Mouse Gdnf-249M Recombinant Mouse Gdnf protein E.coli N/A
Mouse Gdnf-779M Recombinant Mouse Gdnf protein, His-tagged E.coli His
Mouse GDNF-109M Active Recombinant Mouse GDNF Protein E.coli
Mouse Gdnf-066M Active Recombinant Mouse Gdnf Protein E.coli
Mouse Gdnf-278G Active Recombinant Mouse Gdnf Protein CHO
Mouse GDNF-3525M Recombinant Mouse GDNF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Gdnf-30M Recombinant Mouse Gdnf Protein (Ser78-Ile211), C-His tagged, Animal-free, Carrier-free E.coli C-His
Mouse GDNF-3525M-B Recombinant Mouse GDNF Protein Pre-coupled Magnetic Beads HEK293
Mouse Gdnf-1574M Recombinant Mouse Gdnf Protein, His-tagged E.coli N-His
Mouse Gdnf-01M GMP Recombinant Mouse Gdnf Protein, His-Tagged E.coli His
Rat Gdnf-595R Recombinant Rat Gdnf protein E.coli N/A
Rat Gdnf-359R Recombinant Rat Glial Cell Derived Neurotrophic Factor Sf21 Insect Cell N/A
Rat Gdnf-780R Recombinant Rat Gdnf protein, His-tagged E.coli His
Rat Gdnf-250R Recombinant Rat Glial Cell Derived Neurotrophic Factor E.coli N/A
Rat Gdnf-7431R Active Recombinant Rat Gdnf protein, His-tagged Insect Cells His
Rat GDNF-400RCL Recombinant Rat GDNF cell lysate Insect Cell N/A
Rat GDNF-110R Active Recombinant Rat GDNF Protein E.coli
Canine GDNF-1066C Recombinant Canine GDNF protein, hFc-tagged HEK293 hFc
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GDNF Related Articles
  • GDNF Related Research Area

GDNF involved in several pathways and played different roles in them. We selected most pathways GDNF participated on our site, such as Axon guidance, Developmental Biology, NCAM signaling for neurite out-growth, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceSEMA5A;NRG2A;HRAS;CXCR4;CLTA;PPP3CB;PAK7;COL4A5;DCC
Developmental BiologyAP2S1;MED22;CAP2;KDR;MED19;RASGRP4;FGF18B;AP2M1;PCSK6
NCAM signaling for neurite out-growthGDNF;GFRA2;GFRA1;PSPN;NRTN;COL9A1B;ST8SIA2;COL9A1A;GFRA4
NCAM1 interactionsGDNF;NRTN;GFRA2;PSPN;GFRA4;GFRA1;COL9A1B;COL9A1A
Signaling events regulated by Ret tyrosine kinaseGFRA1;DOK4;PDLIM7;DOK6;DOK5;GDNF
Spinal Cord InjuryAIF1;LGALS3;MBP;RTN4;OMG;TNFSF13B;RTN4R;PTPRZ1;GAP43

GDNF has several biochemical functions, for example, growth factor activity, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDNF itself. We selected most functions GDNF had, and list some proteins which have the same functions with GDNF. You can find most of the proteins on our site.

Function Related Protein
growth factor activityEFEMP1;NRG2;IL34;REG1A;KLK1B3;Pdgfa&Pdgfb;NRTN;RABEP1;OGN
protein bindingKDM1A;HSPB6;KLRD1;OLIG3;FBXO25;CDK17;PDZD11;LRRC7;HDGFRP2
protein homodimerization activityMYH7;HM13;PDGFB;CREB3;NOS2;CECR1;ADRA2C;CRYBB2;ACTN3
receptor bindingFASLG;CROT;HLA-B;PAOX;ANGPT2;NPPB;MCHR1;DPP4;HFE2

GDNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDNF here. Most of them are supplied by our site. Hope this information will be useful for your research of GDNF.

AGTRAP; NDUFS6

Battaglia, G; Riozzi, B; et al. Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis. NEUROBIOLOGY OF DISEASE 74:126-136(2015).
Lajoie, JM; Shusta, EV; et al. Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 55:613-631(2015).
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