This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010]
GDNF involved in several pathways and played different roles in them. We selected most pathways GDNF participated on our site, such as Axon guidance, Developmental Biology, NCAM signaling for neurite out-growth, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
GDNF has several biochemical functions, for example, growth factor activity, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDNF itself. We selected most functions GDNF had, and list some proteins which have the same functions with GDNF. You can find most of the proteins on our site.
GDNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDNF here. Most of them are supplied by our site. Hope this information will be useful for your research of GDNF.
Battaglia, G; Riozzi, B; et al. Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis. NEUROBIOLOGY OF DISEASE 74:126-136(2015).
Lajoie, JM; Shusta, EV; et al. Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 55:613-631(2015).