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Recombinant Human RAD1, His-tagged

Cat.No.: RAD1-31287TH
Product Overview: Recombinant full length Human Rad1 with N terminal His tag; 302 amino acids, MWt 33.9kDa.
Description: This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described.
Protein length: 282 amino acids
Conjugation: HIS
Molecular Weight: 33.900kDa inclusive of tags
Source: E. coli
Tissue specificity: Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level).
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMPLLTQQIQDEDDQYSLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFKVQEESVTFRINLTVLLDCLSIFGSSPMPGTLTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMEAFHCNQTQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPESES
Sequence Similarities: Belongs to the rad1 family.
Gene Name: RAD1 RAD1 homolog (S. pombe) [ Homo sapiens ]
Official Symbol: RAD1
Synonyms: RAD1; RAD1 homolog (S. pombe); RAD1 (S. pombe) homolog; cell cycle checkpoint protein RAD1; cell cycle checkpoint protein Hrad1; checkpoint control protein HRAD1; DNA repair exonuclease REC1; exonuclease homolog RAD1; HRAD1; Rad1 like DNA damage checkpoin
Gene ID: 5810
mRNA Refseq: NM_002853
Protein Refseq: NP_002844
MIM: 603153
Uniprot ID: O60671
Chromosome Location: 5p13
Pathway: Activation of ATR in response to replication stress, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; G2/M Checkpoints, organism-specific biosystem; Regulation of Telomerase, organism-specific biosystem;
Function: 3-5 exonuclease activity; damaged DNA binding; exodeoxyribonuclease III activity; hydrolase activity; protein binding;

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