"Icos" Related Products


Recombinant Mouse Inducible T-cell Co-stimulator

Cat. No.: Icos-1747M
Description: Inducible co-stimulator (ICOS) is an inducible homodimeric costimulator protein that is structurally and functionally related to CD28. It is a third member of the CD28/CTLA4 family and it is expressed on activated T cells. ICOS regulates CD28-dependent and CD28-independent CD4 (+) subset (Th1 and Th2) responses. ICOS is a major regulator of the adaptive immune system and therefore, has a protective role in inflammatory autoimmune diseases.
Molecular Weight: The predicted molecular weight of Recombinant Mouse ICOS is Mr 44 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 47 kDa.
Source: Sf 21 Insect Cells.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: Icos inducible T-cell co-stimulator [ Mus musculus ]
Synonyms: Icos; inducible T-cell co-stimulator; H4; AILIM; Ly115; OTTMUSP00000002206
Gene ID: 54167
mRNA Refseq: NM_017480
Protein Refseq: NP_059508
UniProt ID: Q9WVS0
Chromosome Location: 1 C2; 1 32.0 cM
Pathway: Cell adhesion molecules (CAMs); Primary immunodeficiency; T cell receptor signaling pathway
Function: protein binding

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