"RHEB" Related Products


Recombinant Human RHEB, His-tagged

Cat.No.: RHEB-31324TH
Product Overview: RHEB full length protein (Human) with N-terminal His tag, MW ~21kDa.Expressed using baculovirus in Sf9 cells.
Description: This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.
Conjugation: HIS
Tissue specificity: Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Form: Liquid
Storage buffer: Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 0.2mM DTT, pH 7.0
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the small GTPase superfamily. Rheb family.
Gene Name: RHEB Ras homolog enriched in brain [ Homo sapiens ]
Official Symbol: RHEB
Synonyms: RHEB; Ras homolog enriched in brain; Ras homolog enriched in brain 2 , RHEB2; GTP-binding protein Rheb;
Gene ID: 6009
mRNA Refseq: NM_005614
Protein Refseq: NP_005605
MIM: 601293
Uniprot ID: Q15382
Chromosome Location: 7q36
Pathway: Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; Insulin receptor signalling cascade, organism-specific biosystem;
Function: GTP binding; GTPase activity; metal ion binding; nucleotide binding;

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