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Recombinant Human RHEB, His-tagged

Cat.No. : RHEB-31324TH
Product Overview : RHEB full length protein (Human) with N-terminal His tag, MW ~21kDa.Expressed using baculovirus in Sf9 cells.
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  • Gene Information
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Description : This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.
Conjugation : HIS
Tissue specificity : Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Form : Liquid
Storage buffer : Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 0.2mM DTT, pH 7.0
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the small GTPase superfamily. Rheb family.
Gene Name : RHEB Ras homolog enriched in brain [ Homo sapiens ]
Official Symbol : RHEB
Synonyms : RHEB; Ras homolog enriched in brain; Ras homolog enriched in brain 2 , RHEB2; GTP-binding protein Rheb;
Gene ID : 6009
mRNA Refseq : NM_005614
Protein Refseq : NP_005605
MIM : 601293
Uniprot ID : Q15382
Chromosome Location : 7q36
Pathway : Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; Insulin receptor signalling cascade, organism-specific biosystem;
Function : GTP binding; GTPase activity; metal ion binding; nucleotide binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does RHEB interact with the mTOR pathway, and what implications does this have for clinical interventions 05/29/2021

RHEB directly interacts with the mTOR pathway, a key regulator of cell growth. Understanding this interaction provides insights for developing drugs that target this pathway in diseases like cancer.

Are there any experimental drugs targeting RHEB currently in development? 01/15/2020

Some experimental drugs targeting RHEB are in preclinical development, showing promise in modulating cell growth and survival.

In what ways can the clinical application of RHEB be explored in cancer treatment? 04/24/2018

RHEB's involvement in cell growth makes it a potential target for cancer therapy. Understanding its role may lead to the development of targeted therapies.

Are there any ongoing clinical trials involving RHEB protein in cancer research? 02/18/2018

Research is underway to evaluate the therapeutic potential of targeting RHEB in cancer treatment, with several clinical trials exploring its role as a therapeutic target.

How does the dysregulation of RHEB contribute to diseases? 04/23/2017

Dysregulation of RHEB is associated with various diseases, including cancer and neurological disorders, due to its impact on cell growth and survival pathways.

Customer Reviews (3)

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03/07/2020

    Researchers using RHEB protein can benefit from its high purity and quality, ensuring reliable results.

    05/24/2018

      the RHEB protein is available in different formats, including recombinant and purified variants.

      11/13/2017

        This flexibility allows researchers to select the most suitable form for their particular experimental setup, enhancing the efficiency and accuracy of their trials.

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