Recombinant Human RHEB, His-tagged


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Recombinant Human RHEB, His-tagged

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Cat.No. : RHEB-31324TH
Product Overview : RHEB full length protein (Human) with N-terminal His tag, MW ~21kDa.Expressed using baculovirus in Sf9 cells.
Description : This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.
Conjugation : HIS
Tissue specificity : Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Form : Liquid
Storage buffer : Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 0.2mM DTT, pH 7.0
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the small GTPase superfamily. Rheb family.
Gene Name : RHEB Ras homolog enriched in brain [ Homo sapiens ]
Official Symbol : RHEB
Synonyms : RHEB; Ras homolog enriched in brain; Ras homolog enriched in brain 2 , RHEB2; GTP-binding protein Rheb;
Gene ID : 6009
mRNA Refseq : NM_005614
Protein Refseq : NP_005605
MIM : 601293
Uniprot ID : Q15382
Chromosome Location : 7q36
Pathway : Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; Insulin receptor signalling cascade, organism-specific biosystem;
Function : GTP binding; GTPase activity; metal ion binding; nucleotide binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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