| Description : |
This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. |
| Protein length : |
377 amino acids |
| Molecular Weight : |
67.470kDa inclusive of tags |
| Source : |
Wheat germ |
| Biological activity : |
useful for Antibody Production and Protein Array |
| Form : |
Liquid |
| Purity : |
Proprietary Purification |
| Storage buffer : |
pH: 8.00Constituents:0.31% Glutathione, 0.79% Tris HClNote: Glutathione is reduced |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
MDGTEIAVSPRSLHSELMCPICLDM LKNTMTTKECLHRFCSDCIVTALRS GNKECPTCRKKLVSKRSLRPDPNFD ALISKIYPSREEYEAHQDRVLIRLS RLHNQQALSSSIEEGLRMQAMHRAQ RVRRPIPGSDQTTTMSGGEGEPGEG EGDGEDVSSDSAPDSAPGPAPKRPR GGGAGGSSVGTGGGGTGGVGGGAGS EDSGDRGGTLGGGTLGPPSPPGAPS PPEPGGEIELVFRPHPLLVEKGEYC QTRYVKTTGNATVDHLSKYLALRIA LERRQQQEAGEPGGPGGGASDTGGP DGCGGEGGGAGGGDGPEEPALPSLE GVSEKQYTIYIAPGGGAFTTLNGSL TLELVNEKFWKVSRPLELCYAPTKD PK |
| Sequence Similarities : |
Contains 1 RING-type zinc finger. |
