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Recombinant Human RTKN

Cat.No.: RTKN-27494TH
Product Overview: Recombinant fragment, corresponding to amino acids 1-89 of Human RTKN with proprietary tag, approximately 37kDa.
Description: This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Source: E. coli
Tissue specificity: Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 50mM Tris HCl, 2mM DTE (1, 4-Dithioerythritol), 100mM Sodium chloride, pH 7.5
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Contains 1 PH domain.Contains 1 REM (Hr1) repeat.
Gene Name: RTKN rhotekin [ Homo sapiens ]
Official Symbol: RTKN
Synonyms: RTKN; rhotekin; B5;
Gene ID: 6242
mRNA Refseq: NM_001015055
Protein Refseq: NP_001015055
MIM: 602288
Uniprot ID: Q9BST9
Chromosome Location: 2p13.1
Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; G13 Signaling Pathway, organism-specific biosystem;
Function: GTP binding; GTP-Rho binding; GTPase inhibitor activity; nucleotide binding; protein binding;

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