Recombinant Human RTKN

• Cat.No.: RTKN-27494TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-89 of Human RTKN with proprietary tag, approximately 37kDa.

Specification

• Description: This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: E. coli
• Tissue specificity: Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50mM Tris HCl, 2mM DTE (1, 4-Dithioerythritol), 100mM Sodium chloride, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 PH domain.Contains 1 REM (Hr1) repeat.

Gene Information

• Gene Name: RTKN rhotekin [ Homo sapiens ]
• Official Symbol: RTKN
• Synonyms: RTKN; rhotekin; B5
• Gene ID: 6242
• mRNA Refseq: NM_001015055
• Protein Refseq: NP_001015055
• MIM: 602288
• Uniprot ID: Q9BST9
• Chromosome Location: 2p13.1
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; G13 Signaling Pathway, organism-specific biosystem
• Function: GTP binding; GTP-Rho binding; GTPase inhibitor activity; nucleotide binding; protein binding

Reviews

07/21/2022

They can offer specialized formulations, concentrations, or modifications of RTKN protein to suit unique experimental requirements.

03/23/2022

Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with RTKN.

12/27/2021

The manufacturer can further support researchers by providing customized solutions tailored to their specific needs.

Q&As

Is RTKN a potential therapeutic target in cancer treatment?

Some studies propose RTKN as a potential therapeutic target for cancer, as inhibiting its activity may impede tumor progression.

How does RTKN contribute to cellular signaling pathways?

RTKN is known to modulate signaling pathways, including those associated with cell survival, proliferation, and differentiation.

How is RTKN linked to neurodegenerative diseases?

Some studies suggest that RTKN may be associated with neurodegenerative disorders, possibly influencing neuronal function.

Are there any known genetic mutations in the RTKN gene associated with diseases?

Genetic variations in the RTKN gene have been investigated for potential links to certain diseases, but more research is needed to establish clear associations.

Can RTKN be targeted for drug development?

The potential for developing drugs targeting RTKN is being explored, with a focus on its role in diseases such as cancer.