"Il1rl1" Related Products

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Recombinant Mouse Interleukin 1 Receptor-like 1, Fc-tagged

Cat. No.: Il1rl1-1752M
Product Overview: Recombinant Mouse Il1rl1 encoding the extracellular domain (amino acid residues Met 1 - Ser 342) was fused to the Fc region of human IgG1 via a polypeptide linker, inserted into a suitable baculovirus expression vector and expressed inSf21 cells.
Description: ST2 belongs to the immunoglobulin superfamily and bears significant amino acid identity (~25%) to the extracellular portion of both type I and type II interleukin 1 receptors (IL-1R). Some of the intracellular residues that are required for signal transduction through the IL-1R and are conserved in the Drosophila Toll protein are also found in the membrane form of ST2. Furthermore, the gene for ST2 was mapped to mouse chromosome 1 closely linked to the il-1r locus containing both type I and type II receptor genes in support of their common ancestry.
Molecular Weight: The predicted molecular weight of Recombinant Mouse IL-1 R4 is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 73 kDa.
Source: Sf 21 Insect Cells.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Endotoxin: <0.1 EU/µg as determined by the LAL method.
Biological Activity: The biological activity of Mouse IL-1 R4 was determined by its ability to bind rmIL-33 in a functional ELISA type binding assay. The estimated KD is < 50 nM.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: Il1rl1 interleukin 1 receptor-like 1 [ Mus musculus ]
Synonyms: Il1rl1; interleukin 1 receptor-like 1; T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1; T1; lymphocyte antigen 84; ST2; T1 gene
Gene ID: 17082
mRNA Refseq: NM_001025602
Protein Refseq: NP_001020773
UniProt ID: P14719
Chromosome Location: 1 B; 1 20.0 cM
Function: interleukin-1 receptor activity; interleukin-33 binding; interleukin-33 receptor activity; protein binding; receptor activity; transmembrane receptor activity

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