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Recombinant Human RXRB, His-tagged

Cat.No. : RXRB-31124TH
Product Overview : Recombinant full length Human Retinoid X Receptor beta with His tag expressed in a baculovirus system under the control of a T7 promoter, approximately 57kDa, amino acids 1-533,
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Description : This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.
Conjugation : HIS
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name : RXRB retinoid X receptor, beta [ Homo sapiens ]
Official Symbol : RXRB
Synonyms : RXRB; retinoid X receptor, beta; retinoic acid receptor RXR-beta; H 2RIIBP; NR2B2; RCoR 1;
Gene ID : 6257
mRNA Refseq : NM_021976
Protein Refseq : NP_068811
MIM : 180246
Uniprot ID : P28702
Chromosome Location : 6p21.3
Pathway : Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Non-small cell lung cancer, organism-specific biosystem;
Function : ligand-regulated transcription factor activity; metal ion binding; protein binding; protein heterodimerization activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do environmental factors like diet and sunlight exposure affect the activity and expression of RXRB? 10/17/2022

Environmental factors like diet and sunlight alter RXRB activity, impacting its role in skin health and metabolic processes.

What are the effects of RXRB dysregulation on cancer development and progression? 06/23/2022

Dysregulation of RXRB can contribute to the development and progression of various cancers.

How does RXRB influence the immune response, especially in autoimmune and inflammatory diseases? 06/29/2021

RXRB modulates the immune system, affecting autoimmune and inflammatory responses.

How does RXRB contribute to metabolic regulation, particularly in lipid metabolism and obesity? 10/01/2020

RXRB is crucial in lipid metabolism, influencing processes related to obesity and metabolic health.

What role does RXRB play in skin health and the development of skin disorders? 08/25/2018

RXRB plays a key role in maintaining skin health and is involved in the pathology of skin disorders.

What is the impact of RXRB on neurodevelopment and neurodegenerative diseases? 04/17/2018

RXRB impacts neurodevelopment and is implicated in the progression of neurodegenerative diseases.

How does RXRB interact with retinoic acid and other ligands to regulate gene expression? 01/17/2018

RXRB binds retinoic acid and other ligands to regulate genes involved in development, metabolism, and cell differentiation.

Customer Reviews (3)

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Reviews
10/19/2022

    Timely support for protein expression optimization, appreciated assistance.

    04/08/2021

      High-quality protein characterization, fundamental for our research.

      05/25/2018

        Accurate protein structural analysis, indispensable for our investigations.

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