"SAP18" Related Products

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Recombinant Human SAP18, His-tagged

Cat.No.: SAP18-31375TH
Product Overview: Recombinant full length human SAP18 fused to His tag at N-terminus; amino acids 1-153 , 19.7kDa.
Description: Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.
Conjugation: HIS
Source: E. coli
Tissue specificity: Ubiquitous.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 30% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY
Sequence Similarities: Belongs to the SAP18 family.
Gene Name: SAP18 Sin3A-associated protein, 18kDa [ Homo sapiens ]
Official Symbol: SAP18
Synonyms: SAP18; Sin3A-associated protein, 18kDa; sin3A associated protein, 18kDa; histone deacetylase complex subunit SAP18; 2HOR0202; MGC27131; SAP18p;
Gene ID: 10284
mRNA Refseq: NM_005870
Protein Refseq: NP_005861
MIM: 602949
Uniprot ID: O00422
Chromosome Location: 13q12.11
Pathway: Exon junction complex (EJC), organism-specific biosystem; Hedgehog Signaling Pathway, organism-specific biosystem; Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem; RNA transport, organism-specific biosystem; RNA transport, conserved biosystem;
Function: protein binding; transcription corepressor activity;

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