"SELL" Related Products

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Recombinant Human SELL, His-tagged

Cat.No.: SELL-27884TH
Product Overview: Recombinant fragment correspondingn to the mature form of human CD62L (aminoacids 39/332 of the precursor) with an N-termial hexahistidine tag
Description: This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene.
Conjugation: HIS
Source: E. coli
Tissue specificity: Expressed in B cell lines and T lymphocytes.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 20mM Tris, pH 8
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids: WT YHYSEKPMNW QRARRFCRDN YTDLVAIQNK AEIEYLEKTL PFSRSYYWIG IRKIGGIWTW VGTNKSLTEE AENWGDGEPN NKKNKEDCVE IYIKRNKDAG KWNDDACHKL KAALCYTASC QPWSCSGHGE CVEIINNYTC NCDVGYYGPQ CQFVIQCEPL EAPELGTMDC THPLGNFSFS SQCAFSCSEG TNLTGIEETT CGPFGNWSSP EPTCQVIQCE PLSAPDLGIM NCSHPLASFS FTSACTFICS EGTELIGKKK TICESSGIWS NPSPICQKLD KS
Sequence Similarities: Belongs to the selectin/LECAM family.Contains 1 C-type lectin domain.Contains 1 EGF-like domain.Contains 2 Sushi (CCP/SCR) domains.
Gene Name: SELL selectin L [ Homo sapiens ]
Official Symbol: SELL
Synonyms: SELL; selectin L; LNHR, LYAM1, lymphocyte adhesion molecule 1; L-selectin; CD62L; hLHRc; LAM 1; LAM1; Leu 8; LSEL; Lyam 1; PLNHR;
Gene ID: 6402
mRNA Refseq: NM_000655
Protein Refseq: NP_000646
MIM: 153240
Uniprot ID: P14151
Chromosome Location: 1q23-q25
Pathway: Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function: carbohydrate binding; cell adhesion molecule binding; glycosphingolipid binding; heparin binding; protease binding;

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