Recombinant Human Lysine (K)-specific Demethylase 4C, GST-tagged

• Cat.No.: KDM4C-428H
• Product Overview: Recombinant Human JMJD2C (amino-acids 2-372), with N-terminal GST tag expressed in aBaculovirus infected Sf9cell expression system. MW = 69 kDa.

Specification

• Cat. No.: KDM4C-428H
• Description: Lysine-specific demethylase 4C is an enzyme that in humans is encoded by the KDM4C gene. This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.
• Source: Sf9 cell.
• Purity: >80%.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT.
• Stability: >6 months at –80°C.

Gene Information

• Gene Name: KDM4C lysine (K)-specific demethylase 4C [ Homo sapiens ]
• Synonyms: KDM4C; lysine (K)-specific demethylase 4C; GASC1; JHDM3C; JMJD2C; FLJ25949; KIAA0780; bA146B14.1; jumonji domain containing 2C; gene amplified in squamous cell carcinoma 1; JmjC domain-containing histone demethylation protein 3C; EC 1.14.11.-
• Gene ID: 23081
• mRNA Refseq: NM_001146694
• Protein Refseq: NP_001140166
• MIM: 605469
• UniProt ID: Q9H3R0
• Chromosome Location: 9p24.1
• Function: iron ion binding; molecular_function; oxidoreductase activity; oxidoreductase activity, acting on single donors with; incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein binding; zinc ion binding