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Recombinant Mouse Kinase Insert Domain Protein Receptor, Fc-His

Cat. No.: Kdr-1786M
Product Overview: Recombinant mouse VEGFR2 encoding amino acid residues 1-762 of the extracellular domain was fused to the 6X his-tagged Fc of human IgG1 via the peptide (IEGRMD). The chimeric protein was expressed in NSO cells.
Description: Vascular endothelial growth factor receptor 2 (VEGF R2) is a transmembrane glycoprotein that is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration, and differentiation.
Molecular Weight: The predicted molecular weight of Recombinant Mouse VEGF R2 is Mr 110 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 166-191 kDa.
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >90% by SDS Page and analyzed by silver stain.
Formulation: This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Biological Activity: The biological activity of Mouse VEGFR2 was determined by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells. The expected ED50 for this effect is typically 10 - 30 ng/ml in the presence of 5 ng/ml of rmVEGF.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: Kdr kinase insert domain protein receptor [ Mus musculus ]
Synonyms: Kdr; kinase insert domain protein receptor; Flk1; Ly73; Flk-1; Krd-1; VEGFR2; VEGFR-2; sVEGFR-2; 6130401C07; VEGF receptor-2; OTTMUSP00000023578; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; vascular endothelial growth factor receptor- 2; soluble vascular endothelial growth factor receptor 2; EC 2.7.10.1
Gene ID: 16542
mRNA Refseq: NM_010612
Protein Refseq: NP_034742
UniProt ID: P35918
Chromosome Location: 5 C3.3; 5 42.0 cM
Pathway: Cytokine-cytokine receptor interaction; Endocytosis; Focal adhesion; VEGF signaling pathway
Function: ATP binding; growth factor binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity

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