Recombinant Human SIRT6, T7 -tagged SIRT6-28517TH

Cat.No.:	SIRT6-28517TH
Product Overview:	Recombinant full length Human SIRT6 with N-terminal proprietary tag, 65 kDa.
Description:	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
Conjugation:	T7
Source:	E. coli
Form:	Liquid
Storage buffer:	Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 100mM Sodium chloride, pH 8
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities:	Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain.

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Gene Name:	SIRT6 sirtuin 6 [ Homo sapiens ]
Official Symbol:	SIRT6
Synonyms:	SIRT6; sirtuin 6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; NAD-dependent deacetylase sirtuin-6;
Gene ID:	51548
mRNA Refseq:	NM_016539
Protein Refseq:	NP_057623
MIM:	606211
Uniprot ID:	Q8N6T7
Chromosome Location:	19p13.3
Pathway:	Signaling events mediated by HDAC Class I, organism-specific biosystem;
Function:	NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific);