Recombinant Human SIRT6, T7 -tagged
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Cat.No. : | SIRT6-28517TH |
Product Overview : | Recombinant full length Human SIRT6 with N-terminal proprietary tag, 65 kDa. |
Description : | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants. |
Conjugation : | T7 |
Source : | E. coli |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 100mM Sodium chloride, pH 8 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain. |
Gene Name : | SIRT6 sirtuin 6 [ Homo sapiens ] |
Official Symbol : | SIRT6 |
Synonyms : | SIRT6; sirtuin 6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; NAD-dependent deacetylase sirtuin-6; |
Gene ID : | 51548 |
mRNA Refseq : | NM_016539 |
Protein Refseq : | NP_057623 |
MIM : | 606211 |
Uniprot ID : | Q8N6T7 |
Chromosome Location : | 19p13.3 |
Pathway : | Signaling events mediated by HDAC Class I, organism-specific biosystem; |
Function : | NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); |
◆ Recombinant Protein
Sirt6-5885M | Recombinant Mouse Sirt6 Protein, Myc/DDK-tagged | +Inquiry |
SIRT6-24H | Recombinant Human SIRT6 Protein, His-tagged | +Inquiry |
SIRT6-28517H | Recombinant Human SIRT6 Protein, GST-tagged | +Inquiry |
SIRT6-3378C | Recombinant Chicken SIRT6 | +Inquiry |
Sirt6-1381M | Recombinant Mouse Sirt6 protein, His-tagged | +Inquiry |
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◆ Lysates
SIRT6-1829HCL | Recombinant Human SIRT6 293 Cell Lysate | +Inquiry |
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◆ Assay kits
Kit-2341 | SIRT6 Inhibitor Screening Kit (Fluorometric) | +Inquiry |
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