Recombinant Human SIRT7, T7 -tagged

• Cat.No.: SIRT7-30848TH
• Product Overview: Recombinant full length Human SIRT7 , with N terminal proprietary tag.

Specification

• Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
• Conjugation: T7
• Source: E. coli
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain.

Gene Information

• Gene Name: SIRT7 sirtuin 7 [ Homo sapiens ]
• Official Symbol: SIRT7
• Synonyms: SIRT7; sirtuin 7; sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7; NAD-dependent deacetylase sirtuin-7
• Gene ID: 51547
• mRNA Refseq: NM_016538
• Protein Refseq: NP_057622
• MIM: 606212
• Uniprot ID: Q9NRC8
• Chromosome Location: 17q25.3
• Pathway: Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem
• Function: NAD+ binding; hydrolase activity; metal ion binding; protein binding; zinc ion binding