Recombinant Human SIRT7, His-tagged

• Cat.No.: SIRT7-30867TH
• Product Overview: Recombinant full length Human SIRT7 with N terminal His tag; MWt 46 kDa.

Specification

• Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
• Protein length: 400 amino acids
• Conjugation: HIS
• Molecular Weight: 46.000kDa inclusive of tags
• Source: Baculovirus infected sf9 cells
• Biological activity: The Specific activity of SIRT7-30867TH was determined to be 140 RLU/min/ng.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain.

Gene Information

• Gene Name: SIRT7 sirtuin 7 [ Homo sapiens ]
• Official Symbol: SIRT7
• Synonyms: SIRT7; sirtuin 7; sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7; NAD-dependent deacetylase sirtuin-7
• Gene ID: 51547
• mRNA Refseq: NM_016538
• Protein Refseq: NP_057622
• MIM: 606212
• Uniprot ID: Q9NRC8
• Chromosome Location: 17q25.3
• Pathway: Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem
• Function: NAD+ binding; hydrolase activity; metal ion binding; protein binding; zinc ion binding