Cat.No.:	SIRT7-30867TH
Product Overview:	Recombinant full length Human SIRT7 with N terminal His tag; MWt 46 kDa.
Description:	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Protein length:	400 amino acids
Conjugation:	HIS
Molecular Weight:	46.000kDa inclusive of tags
Source:	Baculovirus infected sf9 cells
Biological activity:	The Specific activity of SIRT7-30867TH was determined to be 140 RLU/min/ng.
Form:	Liquid
Purity:	>95% by SDS-PAGE
Storage buffer:	Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.0
Storage:	Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities:	Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain.

Gene Name:	SIRT7 sirtuin 7 [ Homo sapiens ]
Official Symbol:	SIRT7
Synonyms:	SIRT7; sirtuin 7; sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7; NAD-dependent deacetylase sirtuin-7;
Gene ID:	51547
mRNA Refseq:	NM_016538
Protein Refseq:	NP_057622
MIM:	606212
Uniprot ID:	Q9NRC8
Chromosome Location:	17q25.3
Pathway:	Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem;
Function:	NAD+ binding; hydrolase activity; metal ion binding; protein binding; zinc ion binding;

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