Recombinant Human SLC12A1

• Cat.No.: SLC12A1-31410TH
• Product Overview: Recombinant fragment of Human SLC12A1 with N-terminal proprietary tag.Mol Wt 35.86 kDa inclusive of tag.

Specification

• Description: This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henles loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
• Protein length: 93 amino acids
• Molecular Weight: 35.860kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Kidney specific.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: AKTDASFHAYDSHTNTYYLQTFGHN TMDAVPKIEYYRNTGSISGPKVNRP SLLEIHEQLAKNVAVTPSSADRVAN GDGIPGDEQAENKEDDQA
• Sequence Similarities: Belongs to the SLC12A transporter family.

Gene Information

• Gene Name: SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporters), member 1 [ Homo sapiens ]
• Official Symbol: SLC12A1
• Synonyms: SLC12A1; solute carrier family 12 (sodium/potassium/chloride transporters), member 1; solute carrier family 12 member 1; NKCC2
• Gene ID: 6557
• mRNA Refseq: NM_000338
• Protein Refseq: NP_000329
• MIM: 600839
• Uniprot ID: Q13621
• Chromosome Location: 15q15-q21
• Pathway: Cation-coupled Chloride cotransporters, organism-specific biosystem; SLC-mediated transmembrane transport, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem; Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem
• Function: ion transmembrane transporter activity; sodium:potassium:chloride symporter activity; symporter activity; transporter activity