Recombinant Human SMAD1

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Recombinant Human SMAD1

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Cat.No. : SMAD1-30445TH
Product Overview : Recombinant full length Human Smad1 with N-terminal proprietary tag; amino acids 1-465, 83kDa.
Description : The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Source : E. coli
Tissue specificity : Ubiquitous. Highest expression seen in the heart and skeletal muscle.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the dwarfin/SMAD family.Contains 1 MH1 (MAD homology 1) domain.Contains 1 MH2 (MAD homology 2) domain.
Gene Name : SMAD1 SMAD family member 1 [ Homo sapiens ]
Official Symbol : SMAD1
Synonyms : SMAD1; SMAD family member 1; MAD, mothers against decapentaplegic homolog 1 (Drosophila) , MADH1, SMAD, mothers against DPP homolog 1 (Drosophila); mothers against decapentaplegic homolog 1; JV4 1; MADR1;
Gene ID : 4086
mRNA Refseq : NM_001003688
Protein Refseq : NP_001003688
MIM : 601595
Uniprot ID : Q15797
Chromosome Location : 4q31.21
Pathway : ALK1 signaling events, organism-specific biosystem; ALK2 signaling events, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; ErbB1 downstream signaling, organism-specific biosystem;
Function : I-SMAD binding; co-SMAD binding; identical protein binding; protein binding; protein kinase binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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