Recombinant Human SNUPN, His-tagged

• Cat.No.: SNUPN-30607TH
• Product Overview: Recombinant full length Human SNURPORTIN1 with N-terminal His tag; 380aa, 43.3 kDa.

Specification

• Description: The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
• Protein length: 360 amino acids
• Conjugation: HIS
• Molecular Weight: 43.300kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.24% Tris, 0.03% DTT, 0.58% Sodium chloride, 10% Glycerol
• Storage: Please see Notes section
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMEELSQALASSFSVSQDLNS TAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVN HARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYAN QLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTS AYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVN QTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGE KTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFY HKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPD YAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLS TPKLKGSSHSPDHPGCLMEN
• Sequence Similarities: Belongs to the snurportin family.Contains 1 IBB domain.

Gene Information

• Gene Name: SNUPN snurportin 1 [ Homo sapiens ]
• Official Symbol: SNUPN
• Synonyms: SNUPN; snurportin 1; RNA, U transporter 1 , RNUT1; snurportin-1; SNURPORTIN 1; Snurportin1
• Gene ID: 10073
• mRNA Refseq: NM_001042581
• Protein Refseq: NP_001036046
• MIM: 607902
• Uniprot ID: O95149
• Chromosome Location: 15q24.2
• Pathway: Metabolism, organism-specific biosystem; Metabolism of RNA, organism-specific biosystem; Metabolism of non-coding RNA, organism-specific biosystem; RNA transport, organism-specific biosystem; RNA transport, conserved biosystem
• Function: RNA cap binding; protein transporter activity