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Recombinant Human SOD2, His-tagged

Cat.No. : SOD2-30343TH
Product Overview : Recombinant full length Human Superoxide Dismutase 2 with His tag; 219 amino acids with tag, MWt 24.4 kDa.
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Description : This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Conjugation : HIS
Source : E. coli
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHMKHSLPDLPYDYGALEPHIN AQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIA LQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKR DFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAA CPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKA IWNVINWENVTERYMACKK
Sequence Similarities : Belongs to the iron/manganese superoxide dismutase family.
Gene Name : SOD2 superoxide dismutase 2, mitochondrial [ Homo sapiens ]
Official Symbol : SOD2
Synonyms : SOD2; superoxide dismutase 2, mitochondrial; superoxide dismutase [Mn], mitochondrial;
Gene ID : 6648
mRNA Refseq : NM_000636
Protein Refseq : NP_000627
MIM : 147460
Uniprot ID : P04179
Chromosome Location : 6q25
Pathway : FoxO family signaling, organism-specific biosystem; Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem; Oxidative Stress, organism-specific biosystem; Peroxisome, organism-specific biosystem;
Function : DNA binding; identical protein binding; manganese ion binding; manganese ion binding; metal ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the current research directions regarding SOD2? 08/12/2021

Current research on SOD2 focuses on understanding its role in different disease contexts and identifying potential therapeutic targets. Investigations are underway to elucidate the molecular mechanisms underlying SOD2 regulation, its involvement in age-related diseases, and the development of novel strategies to enhance SOD2 activity for therapeutic purposes. Additionally, studies are exploring the interplay between SOD2 and other cellular processes, aiming to uncover new insights into its biological functions.

What therapeutic strategies target SOD2 for disease treatment? 11/06/2020

Several approaches have been explored to enhance SOD2 activity as a potential therapeutic strategy. These include the use of small molecule activators, such as resveratrol and melatonin, which can upregulate SOD2 expression and improve cellular antioxidant defense. Additionally, gene therapy approaches aiming to increase SOD2 levels or activity have shown promise in preclinical studies.

How does SOD2 contribute to cellular senescence and aging? 10/23/2020

As cells age, the expression and activity of SOD2 decline, resulting in increased levels of reactive oxygen species (ROS) and oxidative damage. The accumulation of ROS can promote cellular senescence, a state of irreversible growth arrest. SOD2 plays a crucial role in mitigating ROS-mediated DNA damage and preserving cellular integrity, thus influencing the aging process.

How is the expression of SOD2 regulated? 09/25/2020

The expression of SOD2 is regulated by various transcription factors, including nuclear factor erythroid 2-related factor 2 (NRF2) and forkhead box O3 (FOXO3). These transcription factors bind to the promoter region of the SOD2 gene and initiate its transcription. Additionally, post-translational modifications, such as acetylation and phosphorylation, can also modulate the activity and stability of SOD2.

What is the significance of SOD2 polymorphisms in disease susceptibility? 02/28/2019

Certain genetic variations or polymorphisms in the SOD2 gene have been associated with altered enzyme activity and increased susceptibility to certain diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. These polymorphisms can affect the antioxidant capacity of SOD2, leading to an imbalance between reactive oxygen species generation and scavenging, thereby contributing to disease pathogenesis.

What is the primary function of SOD2 in cellular physiology? 11/17/2018

SOD2, also known as mitochondrial superoxide dismutase, is an enzyme responsible for the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen within the mitochondria. This antioxidant activity helps to protect cells from oxidative stress and maintain redox homeostasis in the mitochondria.

How does SOD2 interact with other proteins and signaling pathways? 02/08/2016

SOD2 is known to interact with various proteins and signaling pathways to regulate cellular processes. For instance, SOD2 interacts with the nuclear factor kappa B (NF-κB) pathway, modulating its activity and downstream gene expression. SOD2 also interacts with other antioxidant enzymes, such as catalase and glutathione peroxidase, forming a coordinated antioxidant defense system within cells.

Customer Reviews (3)

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Reviews
01/10/2021

    It has earned my trust with its outstanding stability and reproducibility.

    10/04/2016

      After using this protein reagent, my protein gel electrophoresis results are notably clear, aiding in analysis and interpretation.

      07/30/2016

        Engaging confidently in academic discussions and collaborations with peers is possible due to this reagent's exceptional performance.

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