Recombinant Human Poly (ADP-ribose) Polymerase 3, GST-tagged

• Cat.No.: PARP3-434H
• Product Overview: Recombinant Human PARP3, full length with N-terminal GST tag expressed in aBaculovirusinfected Sf9 cell expression system. MW = 87kDa.

Specification

• Cat. No.: PARP3-434H
• Description: Poly (ADP-ribose) polymerase (PARP) is a protein involved in a number of cellular processes involving mainly DNA repair and programmed cell death.
• Source: Sf9 cell.
• Purity: >80%.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT.
• Stability: >6 months at –80°C.

Gene Information

• Gene Name: PARP3 poly (ADP-ribose) polymerase family, member 3 [ Homo sapiens ]
• Synonyms: PARP3; poly (ADP-ribose) polymerase 3; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3; NAD+ ADP-ribosyltransferase 3; poly(ADP-ribose) synthetase-3; IRT1; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3; EC 2.4.2.30
• Gene ID: 10039
• mRNA Refseq: NM_001003931
• Protein Refseq: NP_001003931
• MIM: 607726
• UniProt ID: Q9Y6F1
• Chromosome Location: 3p21.31-p21.1
• Pathway: Base excision repair
• Function: NAD+ ADP-ribosyltransferase activity; identical protein binding; protein N-terminus binding; transcription factor binding; transferase activity, transferring glycosyl groups

Reviews

01/25/2023

An additional advantage of selecting the PARP3 protein is the outstanding technical support offered by its manufacturer.

09/09/2019

Their unwavering commitment to customer satisfaction assures me that any challenges or queries I may encounter will be expertly resolved.

01/13/2016

The combination of the protein's excellence and the manufacturer's exceptional technical support equips me with the necessary resources to overcome experimental obstacles and achieve groundbreaking results.

Q&As

How does PARP3 interact with other proteins in the DNA repair pathway?

PARP3 interacts with various proteins involved in DNA repair, forming complexes that coordinate the repair process.

How does the dysregulation of PARP3 relate to cancer development?

Dysregulation of PARP3 can lead to genomic instability and impaired DNA repair, contributing to the development and progression of certain cancers.

Are there any diagnostic tools specifically detecting PARP3 activity?

While there are research tools for studying PARP3 activity in the laboratory, clinical diagnostic tools targeting PARP3 are still in the early stages of development.

Is PARP3 involved in the regulation of immune responses?

Emerging research suggests that PARP3 may play a role in immune regulation, and its modulation could potentially impact immune responses in diseases such as cancer.

Are there any clinical trials involving PARP3 inhibitors?

Some clinical trials are exploring the efficacy and safety of PARP inhibitors, and their potential application in cancers where PARP3 is implicated.