Recombinant Human SRM, His-tagged

• Cat.No.: SRM-30397TH
• Product Overview: Recombinant full length Human Spermidine synthase with an N terminal His tag. Predicted mwt: 36 kDa.

Specification

• Description: The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.
• Protein length: 302 amino acids
• Conjugation: HIS
• Molecular Weight: 36.000kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MEPGPDGPAA SGPAAIREGW FRETCSLWPG QALSLQVEQL LHHRRSRYQD ILVFRSKTYG NVLVLDGVIQ CTERDEFSYQ EMIANLPLCS HPNPRKVLII GGGDGGVLRE VVKHPSVESV VQCEIDEDVI QVSKKFLPGM AIGYSSSKLT LHVGDGFEFM KQNQDAFDVI ITDSSDPMGP AESLFKESYY QLMKTALKED GVLCCQGECQ WLHLDLIKEM RQFCQSLFPV VAYAYCTIPT YPSGQIGFML CSKNPSTNFQ EPVQPLTQQQ VAQMQLKYYN SDVHRAAFVL PEFARKALND VS
• Sequence Similarities: Belongs to the spermidine/spermine synthase family.

Gene Information

• Gene Name: SRM spermidine synthase [ Homo sapiens ]
• Official Symbol: SRM
• Synonyms: SRM; spermidine synthase; SRML1; SPS1
• Gene ID: 6723
• mRNA Refseq: NM_003132
• Protein Refseq: NP_003123
• MIM: 182891
• Uniprot ID: P19623
• Chromosome Location: 1p36-p22
• Pathway: Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Glutathione metabolism, organism-specific biosystem
• Function: protein homodimerization activity; spermidine synthase activity; transferase activity