"PDE11A" Related Products

Recombinant Human Phosphodiesterase 11A, GST-tagged

Cat. No. : PDE11A-441H
Product Overview : Recombinant Human PDE11A, full length with N-terminal GST tag expressed in aBaculovirus infected Sf9 cellexpression system. MW = 131kDa.
Description : Dual 3",5"-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. The 3",5"-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3",5"-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5"-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : Sf9 cell.
Purity : >80%.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT.
Stability : >6 months at –80°C.
Gene Name : PDE11A phosphodiesterase 10A [ Homo sapiens ]
Synonyms : PDE11A; phosphodiesterase 11A; PPNAD2; FLJ23693; MGC133355; MGC133356; EC; EC; OTTHUMP00000205272; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; cyclic nucleotide phosphodiesterase 11A; dual 3",5"-cyclic-AMP and -GMP phosphodiesterase 11A
Gene ID : 50940
mRNA Refseq : NM_001077196
Protein Refseq : NP_001070664
MIM : 604961
UniProt ID : Q9HCR9
Chromosome Location : 2q31.2
Pathway : Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR
Function : 3",5"-cyclic-GMP phosphodiesterase activity; cAMP binding; cGMP binding; hydrolase activity; magnesium ion binding

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