Recombinant Human Phosphodiesterase 11A, GST-tagged

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Recombinant Human Phosphodiesterase 11A, GST-tagged

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Cat. No. : PDE11A-441H
Product Overview : Recombinant Human PDE11A, full length with N-terminal GST tag expressed in aBaculovirus infected Sf9 cellexpression system. MW = 131kDa.
Description : Dual 3",5"-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene. The 3",5"-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3",5"-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5"-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : Sf9 cell.
Purity : >80%.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT.
Stability : >6 months at –80°C.
Gene Name : PDE11A phosphodiesterase 10A [ Homo sapiens ]
Synonyms : PDE11A; phosphodiesterase 11A; PPNAD2; FLJ23693; MGC133355; MGC133356; EC 3.1.4.17; EC 3.1.4.35; OTTHUMP00000205272; cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; cyclic nucleotide phosphodiesterase 11A; dual 3",5"-cyclic-AMP and -GMP phosphodiesterase 11A
Gene ID : 50940
mRNA Refseq : NM_001077196
Protein Refseq : NP_001070664
MIM : 604961
UniProt ID : Q9HCR9
Chromosome Location : 2q31.2
Pathway : Progesterone-mediated oocyte maturation; Purine metabolism; Signaling by GPCR
Function : 3",5"-cyclic-GMP phosphodiesterase activity; cAMP binding; cGMP binding; hydrolase activity; magnesium ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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