| Description : |
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5UTR. |
| Conjugation : |
HIS |
| Source : |
E. coli |
| Tissue specificity : |
Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta. |
| Form : |
Lyophilised:Reconstitute with 99 μl aqua dest. |
| Storage buffer : |
Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
| Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
HQQLPAGILPMVPEVAQAVGVSQGHHTKDFTRAAPNPAKA TVTAMIARELLYGGTSPTAETILKNNISSGHVPHGPLT RPSEQLDYLSRVQGFQVEYKDFPKNNKNEFVSLINCSSQP PLISHGIGKDVESCHDMAALNILKLLSELDQQSTEMPR TGNGPMSVCGRC |
| Sequence Similarities : |
Contains 3 DRBM (double-stranded RNA-binding) domains. |
