| Description : |
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
63 kDa |
| AA Sequence : |
MSQVQVQVQNPSAALSGSQILNKNQ SLLSQPLMSIPSTTSSLPSENAGRP IQNSALPSASITSTSAAAESITPTV ELNALCMKLGKKPMYKPVDPYSRMQ STYNYNMRGGAYPPRYFYPFPVPPL LYQVELSVGGQQFNGKGKTRQAAKH DAAAKALRILQNEPLPERLEVNGRE SEEENLNKSEISQVFEIALKRNLPV NFEVARESGPPHMKNFVTKVSVGEF VGEGEGKSKKISKKNAAIAVLEELK KLPPLPAVERVKPRIKKKTKPIVKP QTSPEYGQGINPISRLAQIQQAKKE KEPEYTLLTERGLPRRREFVMQVKV GNHTAEGTGTNKKVAKRNAAENMLE ILGFKVPQAQPTKPALKSEEKTPIK KPGDGRKVTFFEPGSGDENGTSNKE DEFRMPYLSHQQLPAGILPMVPEVA QAVGVSQGHHTKDFTRAAPNPAKAT VTAMIARELLYGGTSPTAETILKNN ISSGHVPHGPLTRPSEQLDYLSRVQ GFQVEYKDFPKNNKNEFVSLINCSS QPPLISHGIGKDVESCHDMAALNIL KLLSELDQQSTEMPRTGNGPMSVCG RCTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
