Recombinant Human SUMF1, His-tagged

• Cat.No.: SUMF1-30918TH
• Product Overview: Recombinant fragment of Human SUMF1 with an N terminal His tag; 304aa, 34.1kDa.

Specification

• Description: This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.
• Protein length: 284 amino acids
• Conjugation: HIS
• Molecular Weight: 34.100kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Ubiquitous. Highly expressed in kidney, pancreas and liver. Detected at lower levels in leukocytes, lung, placenta, small intestine, skeletal muscle and heart.
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 20% Glycerol, 0.03% DTT, 12.01% Urea
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMVPIPAGVFTMGTDDPQIKQ DGEAPARRVTIDAFYMDAYEVSNTEFEKFVNSTGYLTEAE KFGDSFVFEGMLSEQVKTNIQQAVAAAPWWLPVKGANWRH PEGPDSTILHRPDHPVLHVSWNDAVAYCTWAGKRLPTEAE WEYSCRGGLHNRLFPWGNKLQPKGQHYANIWQGEFPVTNT GEDGFQGTAPVDAFPPNGYGLYNIVGNAWEWTSDWWTVHH SVEETLNPKGPPSGKDRVKKGGSYMCHRSYCYRYRCAARS QNTPDSSASNLGFRCAADRLPTMD
• Sequence Similarities: Belongs to the sulfatase-modifying factor family.

Gene Information

• Gene Name: SUMF1 sulfatase modifying factor 1 [ Homo sapiens ]
• Official Symbol: SUMF1
• Synonyms: SUMF1; sulfatase modifying factor 1; sulfatase-modifying factor 1; FGE; UNQ3037
• Gene ID: 285362
• mRNA Refseq: NM_182760
• Protein Refseq: NP_877437
• MIM: 607939
• Uniprot ID: Q8NBK3
• Chromosome Location: 3p26.1
• Pathway: Lysosome, organism-specific biosystem; Lysosome, conserved biosystem
• Function: binding; metal ion binding; oxidoreductase activity; protein homodimerization activity