Recombinant Human Protein Arginine Methyltransferase 5

• Cat.No.: PRMT5-452H
• Product Overview: Recombinant Human PRMT5, amino-acids 2-end expressed in aFreeStyle 293-F cellsexpression system. MW= 73 kDa.

Specification

• Cat. No.: PRMT5-452H
• Description: Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the PRMT5 gene. Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.
• Source: FreeStyle 293-F cells.
• Purity: >60%.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT.
• Stability: >6 months at –80°C.

Gene Information

• Gene Name: PRMT5 protein arginine methyltransferase 5 [ Homo sapiens ]
• Synonyms: PRMT5; protein arginine methyltransferase 5; JBP1; SKB1; IBP72; SKB1Hs; HRMT1L5; SKB1 homolog; HMT1 hnRNP methyltransferase-like 5; EC 2.1.1.125; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); Protein arginine N-methyltransferase 5; Histone-arginine N-methyltransferase PRMT5; Jak-binding protein 1; 72 kDa ICln-binding protein
• Gene ID: 10419
• mRNA Refseq: NM_001039619
• Protein Refseq: NP_001034708
• MIM: 604045
• UniProt ID: O14744
• Chromosome Location: 14q11.2
• Pathway: Metabolism of non-coding RNA
• Function: histone-arginine N-methyltransferase activity; transferase activity; protein binding; protein-arginine omega-N symmetric methyltransferase activity; methyltransferase activity; ribonucleoprotein binding