Native Human THBS1
Cat.No. : | THBS1-31514TH |
Product Overview : | Full length native Human Thrombospondin isolated from the supernatant of activated platelets |
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- Gene Information
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Description : | The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol and water. |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the thrombospondin family.Contains 3 EGF-like domains.Contains 1 TSP C-terminal (TSPC) domain.Contains 1 TSP N-terminal (TSPN) domain.Contains 3 TSP type-1 domains.Contains 8 TSP type-3 repeats.Contains 1 VWFC domain. |
Publication : |
Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway (2013)
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Gene Name : | THBS1 thrombospondin 1 [ Homo sapiens ] |
Official Symbol : | THBS1 |
Synonyms : | THBS1; thrombospondin 1; thrombospondin-1; THBS; THBS 1; thrombospondin 1p180; TSP; TSP 1; TSP1; |
Gene ID : | 7057 |
mRNA Refseq : | NM_003246 |
Protein Refseq : | NP_003237 |
MIM : | 188060 |
Uniprot ID : | P07996 |
Chromosome Location : | 15q15 |
Pathway : | Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Focal Adhesion, organism-specific biosystem; |
Function : | calcium ion binding; collagen V binding; eukaryotic cell surface binding; fibrinogen binding; fibroblast growth factor 2 binding; |
Products Types
◆ Recombinant Protein | ||
THBS1-355H | Recombinant Human THBS1 Protein, His-tagged | +Inquiry |
THBS1-2189H | Recombinant Human THBS1 Protein, His (Fc)-Avi-tagged | +Inquiry |
THBS1-894H | Recombinant Human THBS1 Protein, MYC/DDK-tagged | +Inquiry |
Thbs1-6407M | Recombinant Mouse Thbs1 Protein, Myc/DDK-tagged | +Inquiry |
Thbs1-10619M | Recombinant Mouse Thbs1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
THBS1-31515TH | Native Human THBS1 | +Inquiry |
THBS1-5524H | Natve Human Thrombospondin | +Inquiry |
THBS1-4946H | Native Human Thrombospondin protein | +Inquiry |
◆ Lysates | ||
THBS1-1101HCL | Recombinant Human THBS1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionTHBS1 is widely expressed but is upregulated in response to injury or in certain disease states.
It can either promote or inhibit cancer progression, depending on the context.
It binds to extracellular matrix components, influencing cell attachment and signaling.
THBS1 acts as an angiogenesis inhibitor, hindering new blood vessel formation.
Therapeutic strategies include targeting THBS1 to modulate its effects in cancer and wound healing.
THBS1 modulates cell adhesion, proliferation, and migration.
Genetic variations in THBS1 have been linked to cardiovascular diseases and cancer risk.
Customer Reviews (3)
Write a reviewQuality exceeded my expectations.
Satisfied customer, will return.
Very pure, excellent results.
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