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Native Human THBS1

Cat.No. : THBS1-31514TH
Product Overview : Full length native Human Thrombospondin isolated from the supernatant of activated platelets
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Description : The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 50% Glycerol and water.
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the thrombospondin family.Contains 3 EGF-like domains.Contains 1 TSP C-terminal (TSPC) domain.Contains 1 TSP N-terminal (TSPN) domain.Contains 3 TSP type-1 domains.Contains 8 TSP type-3 repeats.Contains 1 VWFC domain.
Publication :
Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway (2013)
Gene Name : THBS1 thrombospondin 1 [ Homo sapiens ]
Official Symbol : THBS1
Synonyms : THBS1; thrombospondin 1; thrombospondin-1; THBS; THBS 1; thrombospondin 1p180; TSP; TSP 1; TSP1;
Gene ID : 7057
mRNA Refseq : NM_003246
Protein Refseq : NP_003237
MIM : 188060
Uniprot ID : P07996
Chromosome Location : 15q15
Pathway : Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Focal Adhesion, organism-specific biosystem;
Function : calcium ion binding; collagen V binding; eukaryotic cell surface binding; fibrinogen binding; fibroblast growth factor 2 binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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In which tissues or cell types is THBS1 predominantly expressed? 09/01/2022

THBS1 is widely expressed but is upregulated in response to injury or in certain disease states.

How is THBS1 implicated in cancer progression? 07/10/2021

It can either promote or inhibit cancer progression, depending on the context.

How does THBS1 contribute to cell-matrix interactions? 04/28/2021

It binds to extracellular matrix components, influencing cell attachment and signaling.

What role does THBS1 play in angiogenesis? 09/14/2020

THBS1 acts as an angiogenesis inhibitor, hindering new blood vessel formation.

What therapeutic strategies are being explored targeting THBS1? 03/08/2020

Therapeutic strategies include targeting THBS1 to modulate its effects in cancer and wound healing.

What is the primary function of THBS1 in cellular processes? 06/17/2018

THBS1 modulates cell adhesion, proliferation, and migration.

Are there known genetic variations in THBS1 associated with specific diseases? 02/13/2018

Genetic variations in THBS1 have been linked to cardiovascular diseases and cancer risk.

Customer Reviews (3)

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Reviews
05/14/2022

    Quality exceeded my expectations.

    09/08/2021

      Satisfied customer, will return.

      11/21/2020

        Very pure, excellent results.

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