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Recombinant Human THPO

Cat.No.: THPO-29520TH
Product Overview: Recombinant full length protein (Human)
Description: Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Alternate splicing results in multiple transcript variants of this gene.
Protein length: 174 amino acids
Source: E. coli
Form: Lyophilised
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL
Sequence Similarities: Belongs to the EPO/TPO family.
Gene Name: THPO thrombopoietin [ Homo sapiens ]
Official Symbol: THPO
Synonyms: THPO; thrombopoietin; MGDF; c mpl ligand; megakaryocyte colony stimulating factor; megakaryocyte growth and development factor; megakaryocyte stimulating factor; MPL ligand; MPLLG; myeloproliferative leukemia virus oncogene ligand; thrombopoietin nirs var
Gene ID: 7066
mRNA Refseq: NM_000460
Protein Refseq: NP_000451
MIM: 600044
Uniprot ID: P40225
Chromosome Location: 3q27
Pathway: Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Hemostasis, organism-specific biosystem; Platelet Aggregation (Plug Formation), organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem;
Function: cytokine activity; growth factor activity; hormone activity;

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