Recombinant Human TIAM2, His-tagged

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Recombinant Human TIAM2, His-tagged

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Cat.No. : TIAM2-30624TH
Product Overview : Recombinant fragment, corresponding to amino acids 1134-1701 of Human TIAM2 with N terminal His tag, 568 amino acids, 80kDa,
Description : This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.
Conjugation : HIS
Source : E. coli
Tissue specificity : Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis.
Form : Lyophilised:Reconstitution with 153 μl aqua dest.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : FLTQDEMESL FGSLPEMLEF QKVFLETLED GISASSDFNT LETPSQFRKL LFSLGGSFLY YADHFKLYSG FCANHIKVQK VLERAKTDKA FKAFLDARNP TKQHSSTLES YLIKPVQRVL KYPLLLKELV SLTDQESEEH YHLTEALKAM EKVASHINEM QKIYEDYGTV FDQLVAEQSG TEKEVTELSM GELLMHSTVS WLNPFLSLGK ARKDLELTVF VFKRAVILVY KENCKLKKKL PSNSRPAHNS TDLDPFKFRW LIPISALQVR LGNPAGTENN SIWELIHTKS EIEGRPETIF QLCCSDSESK TNIVKVIRSI LRENFRRHIK CELPLEKTCK DRLVPLKNRV PVSAKLASSR SLKVLKNSSS NEWTGETGKG TLLDSDEGSL SSGTQSSGCP TAEGRQDSKS TSPGKYPHPG LADFADNLIK ESDILSDEDD DHRQTVKQGS PTKDIEIQFQ RLRISEDPDV HPEAEQQPGP ESGEGQKGGE QPKLVRGHFC PIKRKANSTK RDRGTLLKAQ IRHQSLDSQS ENATIDLNSV LEREFSVQSL TSVVSEECFY ETESHGKS
Sequence Similarities : Belongs to the TIAM family.Contains 1 DH (DBL-homology) domain.Contains 1 PDZ (DHR) domain.Contains 2 PH domains.Contains 1 RBD (Ras-binding) domain.
Gene Name : TIAM2 T-cell lymphoma invasion and metastasis 2 [ Homo sapiens ]
Official Symbol : TIAM2
Synonyms : TIAM2; T-cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2; STEF;
Gene ID : 26230
mRNA Refseq : NM_001010927
Protein Refseq : NP_001010927
MIM : 604709
Uniprot ID : Q8IVF5
Chromosome Location : 6q25
Pathway : Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem;
Function : Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; receptor signaling protein activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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