Native Human TIMP1
Cat.No. : | TIMP1-30840TH |
Product Overview : | TIMP1 is purified from stimulated human fibroblasts, and is essentially free of contaminating MMPs or other known TIMPs. |
- Specification
- Gene Information
- Related Products
Description : | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. |
Source : | Human fibroblasts |
Species : | Human |
Form : | Liquid |
Purity : | >95 % by SDS-PAGE. |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.Preservative: NoneConstituents: 50% Glycerol, PBS, pH 7.4 |
Concentration : | 0.1 mg/ml |
Gene Name : | TIMP1 TIMP metallopeptidase inhibitor 1 [ Homo sapiens (human) ] |
Official Symbol : | TIMP1 |
Synonyms : | TIMP1; TIMP metallopeptidase inhibitor 1; EPA; EPO; HCI; CLGI; TIMP; FLJ90373; tissue inhibitor of metalloproteinase 1; erythroid potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); Tissue inhibitor of metalloproteinases; TIMP-1; Collagenase inhibitor; OTTHUMP00000023214; Erythroid-potentiating activity |
Gene ID : | 7076 |
mRNA Refseq : | NM_003254 |
Protein Refseq : | NP_003245 |
MIM : | 305370 |
UniProt ID : | P01033 |
Chromosome Location : | Xp11.3-p11.23 |
Pathway : | Activation of Matrix Metalloproteinases; Matrix Metalloproteinases; Platelet degranulation |
Function : | cytokine activity; protease binding; metal ion binding |
Products Types
◆ Recombinant Protein | ||
TIMP1-1034M | Recombinant Mouse TIMP1 Protein, His-tagged | +Inquiry |
TIMP1-4536R | Recombinant Rhesus Macaque TIMP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Timp1-6436M | Active Recombinant Mouse Timp1 Protein, His-tagged | +Inquiry |
TIMP1-409H | Recombinant Human TIMP1 Protein, His-tagged | +Inquiry |
Timp1-01M | Recombinant Mouse Timp1 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
TIMP1-92H | Native Human TIMP-1 | +Inquiry |
TIMP1-91B | Active Native Bovine Thrombin | +Inquiry |
◆ Lysates | ||
TIMP1-1490RCL | Recombinant Rat TIMP1 cell lysate | +Inquiry |
TIMP1-2678HCL | Recombinant Human TIMP1 cell lysate | +Inquiry |
TIMP1-2376MCL | Recombinant Mouse TIMP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDysregulated TIMP1 expression in cancer can disrupt the balance between MMPs and TIMPs, contributing to excessive extracellular matrix degradation, invasion, and metastasis.
TIMP1 inhibits metalloproteinases by forming a complex with them, blocking their active sites and preventing the degradation of extracellular matrix components.
FXN's nuclear localization is associated with its involvement in DNA repair processes, influencing genomic stability and contributing to the overall cellular response to stress.
TIMP1 has immunomodulatory effects, influencing inflammation by regulating immune cell migration, cytokine production, and interactions with the extracellular matrix.
TIMP1 plays a crucial role in tissue homeostasis and repair by controlling the activity of MMPs, which are involved in remodeling the extracellular matrix during physiological and pathological processes.
Customer Reviews (3)
Write a reviewThe efficient delivery of this product ensured that our research timelines were met without any complications.
Impressed by the professionalism of the customer service team—responsive and knowledgeable about the entire product range.
This recombined protein has become a go-to in our lab due to its reliability and the precision it brings to our experiments.
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