"TNFRSF10A" Related Products


Recombinant Human TNFRSF10A, Fc-tagged

Cat.No.: TNFRSF10A-27024TH
Product Overview: Recombinant fusion protein comprising the extracellular domain (aa 1/238)of Human DR4 and Fc portion of human IgG1.Produced in HEK 293 cells.
Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Conjugation: Fc
Tissue specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
Form: Lyophilised:Reconstitute with 50 μl sterile deionized water. For long term storage or for preparation of more diluted working stock solution, a carrier protein (e.g. 1% serum albumin) should be added to the vial. After reconsitution short term store at 4
Purity: Protein A purified
Storage buffer: Preservative: NoneConstituents: PBS
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Contains 1 death domain.Contains 3 TNFR-Cys repeats.
Gene Name: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a [ Homo sapiens ]
Official Symbol: TNFRSF10A
Synonyms: TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; tumor necrosis factor receptor superfamily member 10A; Apo2; CD261; DR4; TRAILR 1;
Gene ID: 8797
mRNA Refseq: NM_003844
Protein Refseq: NP_003835
MIM: 603611
Uniprot ID: O00220
Chromosome Location: 8p21
Pathway: Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Direct p53 effectors, organism-specific biosystem;
Function: TRAIL binding; cysteine-type endopeptidase activator activity involved in apoptotic process; death receptor activity; protein binding; receptor activity;

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