Recombinant Human TNFRSF10A, Fc-tagged

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Recombinant Human TNFRSF10A, Fc-tagged

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Cat.No. : TNFRSF10A-27024TH
Product Overview : Recombinant fusion protein comprising the extracellular domain (aa 1/238)of Human DR4 and Fc portion of human IgG1.Produced in HEK 293 cells.
Description : The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Conjugation : Fc
Tissue specificity : Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
Form : Lyophilised:Reconstitute with 50 μl sterile deionized water. For long term storage or for preparation of more diluted working stock solution, a carrier protein (e.g. 1% serum albumin) should be added to the vial. After reconsitution short term store at 4
Purity : Protein A purified
Storage buffer : Preservative: NoneConstituents: PBS
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Contains 1 death domain.Contains 3 TNFR-Cys repeats.
Gene Name : TNFRSF10A tumor necrosis factor receptor superfamily, member 10a [ Homo sapiens ]
Official Symbol : TNFRSF10A
Synonyms : TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; tumor necrosis factor receptor superfamily member 10A; Apo2; CD261; DR4; TRAILR 1;
Gene ID : 8797
mRNA Refseq : NM_003844
Protein Refseq : NP_003835
MIM : 603611
Uniprot ID : O00220
Chromosome Location : 8p21
Pathway : Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Direct p53 effectors, organism-specific biosystem;
Function : TRAIL binding; cysteine-type endopeptidase activator activity involved in apoptotic process; death receptor activity; protein binding; receptor activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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