Recombinant Human TNFRSF1B, His-tagged
Cat.No. : | TNFRSF1B-31575TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 23-206 of mature Human TNF Receptor II, containing N-terminal hexahistidine tag. |
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- Gene Information
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Description : | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. |
Conjugation : | HIS |
Source : | E. coli |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, PBS, pH 7.4 |
Storage : | Store at -20°C. Stable for 12 months at -20°C |
Sequences of amino acids : | LPAQVAFT PYAPEPGSTC RLREYYDQTA QMCCSKCSPG QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC SSDQVETQAC TREQNRICTC RPGWYCALSK QEGCRLCAPL RKCRPGFGVA RPGTETSDVV CKPCAPGTFS NTTSSTDICR PHQICNVVAI PGNASMDAVC TSTSPT |
Sequence Similarities : | Contains 4 TNFR-Cys repeats. |
Gene Name : | TNFRSF1B tumor necrosis factor receptor superfamily, member 1B [ Homo sapiens ] |
Official Symbol : | TNFRSF1B |
Synonyms : | TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B; TNFR2; tumor necrosis factor receptor superfamily member 1B; CD120b; p75; TNF R II; TNF R75; TNFBR; TNFR80; |
Gene ID : | 7133 |
mRNA Refseq : | NM_001066 |
Protein Refseq : | NP_001057 |
MIM : | 191191 |
Uniprot ID : | P20333 |
Chromosome Location : | 1p36.22 |
Pathway : | Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Apoptosis, organism-specific biosystem; |
Function : | protein binding; receptor activity; tumor necrosis factor-activated receptor activity; |
Products Types
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◆ Lysates | ||
TNFRSF1B-2632HCL | Recombinant Human TNFRSF1B cell lysate | +Inquiry |
TNFRSF1B-851HCL | Recombinant Human TNFRSF1B cell lysate | +Inquiry |
TNFRSF1B-2192MCL | Recombinant Mouse TNFRSF1B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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