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Recombinant Human TNFRSF1B, His-tagged

Cat.No. : TNFRSF1B-31575TH
Product Overview : Recombinant fragment, corresponding to amino acids 23-206 of mature Human TNF Receptor II, containing N-terminal hexahistidine tag.
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  • Gene Information
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Description : The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Conjugation : HIS
Source : E. coli
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50% Glycerol, PBS, pH 7.4
Storage : Store at -20°C. Stable for 12 months at -20°C
Sequences of amino acids : LPAQVAFT PYAPEPGSTC RLREYYDQTA QMCCSKCSPG QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC SSDQVETQAC TREQNRICTC RPGWYCALSK QEGCRLCAPL RKCRPGFGVA RPGTETSDVV CKPCAPGTFS NTTSSTDICR PHQICNVVAI PGNASMDAVC TSTSPT
Sequence Similarities : Contains 4 TNFR-Cys repeats.
Gene Name : TNFRSF1B tumor necrosis factor receptor superfamily, member 1B [ Homo sapiens ]
Official Symbol : TNFRSF1B
Synonyms : TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B; TNFR2; tumor necrosis factor receptor superfamily member 1B; CD120b; p75; TNF R II; TNF R75; TNFBR; TNFR80;
Gene ID : 7133
mRNA Refseq : NM_001066
Protein Refseq : NP_001057
MIM : 191191
Uniprot ID : P20333
Chromosome Location : 1p36.22
Pathway : Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Apoptosis, organism-specific biosystem;
Function : protein binding; receptor activity; tumor necrosis factor-activated receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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