Recombinant Human SET Domain Containing 2, GST-tagged


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Recombinant Human SET Domain Containing 2, GST-tagged

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Cat. No. : SETD2-460H
Product Overview : Recombinant Human SETD2 (amino acids 915-1211) was expressed in anE.coliexpression system with N-terminal GST tag. MW=59.7 kDa.
Description : Histone-lysine N-methyltransferase SETD2 is an enzyme that in humans is encoded by the SETD2 gene. Huntington"s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs.
Source : E.Coli.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Purity : > 75%.
Stability : >6 months at –80°C.
PDB rendering based on 2a7o. :

Gene Name : SETD2 SET domain containing 2 [ Homo sapiens ]
Synonyms : SET domain containing 2; HYPB; SET2; HIF-1; KMT3A; HBP231; HSPC069; p231HBP; FLJ16420; FLJ22472; FLJ23184; FLJ45883; FLJ46217; KIAA1732; SETD2; huntingtin yeast partner B; lysine N-methyltransferase 3A; SET domain-containing protein 2; huntingtin interacting protein 1; huntingtin-interacting protein B; histone-lysine N-methyltransferase SETD2; EC; HIF1; hSET2; Huntingtin yeast partner B; Huntingtin-interacting protein 1; Huntingtin-interacting protein B; Lysine N-methyltransferase 3A
Gene ID : 29072
mRNA Refseq : NM_014159
Protein Refseq : NP_054878
MIM : 612778
UniProt ID : Q9BYW2
Chromosome Location : 3p21.31
Pathway : Lysine degradation
Function : DNA binding; histone-lysine N-methyltransferase activity; methyltransferase activity; oxidoreductase activity; protein binding; transferase activity; transition metal ion binding

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