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Recombinant Human TNFSF13B, FLAG-tagged

Cat.No. : TNFSF13B-26301TH
Product Overview : Recombinant fragment Human BAFF with an N terminal DDDDK tag; MWt 23 kDa .
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Protein length : 152 amino acids
Conjugation : FLAG
Molecular Weight : 23.000kDa inclusive of tags
Source : E. coli
Tissue specificity : Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver,
Biological activity : Binds to Human and Mouse BAFFR, TACI and BCMA. Relative binding affinity (EC50) for BAFFR (Human): ~3ng/ml.
Form : Lyophilised:Reconstitute with 100μl sterile water to give a final concentration of 0.1mg/ml.
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: PBS
Storage : Store at -20°C, Stable for 6 months at -20°C
Sequence Similarities : Belongs to the tumor necrosis factor family.
Gene Name : TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b [ Homo sapiens ]
Official Symbol : TNFSF13B
Synonyms : TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; TNFSF20; tumor necrosis factor ligand superfamily member 13B; BAFF; BLYS; CD257; TALL 1; TALL1; THANK;
Gene ID : 10673
mRNA Refseq : NM_001145645
Protein Refseq : NP_001139117
MIM : 603969
Uniprot ID : Q9Y275
Chromosome Location : 13q32-q34
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Rheumatoid arthritis, organism-specific biosystem;
Function : cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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