"TNFSF13B" Related Products

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Recombinant Human TNFSF13B, FLAG-tagged

Cat.No.: TNFSF13B-26301TH
Product Overview: Recombinant fragment Human BAFF with an N terminal DDDDK tag; MWt 23 kDa .
Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Protein length: 152 amino acids
Conjugation: FLAG
Molecular Weight: 23.000kDa inclusive of tags
Source: E. coli
Tissue specificity: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver,
Biological activity: Binds to Human and Mouse BAFFR, TACI and BCMA. Relative binding affinity (EC50) for BAFFR (Human): ~3ng/ml.
Form: Lyophilised:Reconstitute with 100μl sterile water to give a final concentration of 0.1mg/ml.
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: PBS
Storage: Store at -20°C, Stable for 6 months at -20°C
Sequence Similarities: Belongs to the tumor necrosis factor family.
Gene Name: TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b [ Homo sapiens ]
Official Symbol: TNFSF13B
Synonyms: TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; TNFSF20; tumor necrosis factor ligand superfamily member 13B; BAFF; BLYS; CD257; TALL 1; TALL1; THANK;
Gene ID: 10673
mRNA Refseq: NM_001145645
Protein Refseq: NP_001139117
MIM: 603969
Uniprot ID: Q9Y275
Chromosome Location: 13q32-q34
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Rheumatoid arthritis, organism-specific biosystem;
Function: cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding;

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