||Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR is a member of the IL-1 receptor family. It acts as a negative regulator of interleukin (IL)-1 and lipopolysaccharide (LPS) signaling. It also plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium.
||The predicted molecular weight of Recombinant Mouse SIGIRR is Mr 39 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 63 kDa.
|State Of Matter:
||>95% by SDS Page and analyzed by silver stain.
||<0.1 ng per 1 µg as determined by the LAL method.
|Storage And Stability:
||The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.