"TOP1" Related Products

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Recombinant Human TOP1, His-tagged

Cat.No.: TOP1-31198TH
Product Overview: Recombinant fragment, corresponding to C terminal domain amino acids 651-765 of HumanTopoisomerase I with His tag expressed in a baculovirus system, approximately 14kDa.
Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
Conjugation: HIS
Biological activity: TOP1-31198TH contains no detectable DNA relaxation activity by itself.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the eukaryotic type I topoisomerase family.
Gene Name: TOP1 topoisomerase (DNA) I [ Homo sapiens ]
Official Symbol: TOP1
Synonyms: TOP1; topoisomerase (DNA) I; DNA topoisomerase 1;
Gene ID: 7150
mRNA Refseq: NM_003286
Protein Refseq: NP_003277
MIM: 126420
Uniprot ID: P11387
Chromosome Location: 20q12-q13.1
Pathway: Caspase cascade in apoptosis, organism-specific biosystem;
Function: ATP binding; DNA binding; DNA topoisomerase (ATP-hydrolyzing) activity; DNA topoisomerase type I activity; chromatin DNA binding;

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