Recombinant Human TPM2, His-tagged

• Cat.No.: TPM2-31626TH
• Product Overview: Recombinant full length Human Tropomyosin 2 Isoform 2 with N terminal His tag; 304 amino acids with tag, MWt 35.1 kDa inclusive of tag.

Specification

• Description: This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Protein length: 284 amino acids
• Conjugation: HIS
• Molecular Weight: 35.100kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 30% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMDAIK KKMQMLKLDKENAIDRAEQAEADKK QAEDRCKQLEEEQQALQKKLKGTED EVEKYSESVKEAQEKLEQAEKKATD AEADVASLNRRIQLVEEELDRAQER LATALQKLEEAEKAADESERGMKVI ENRAMKDEEKMELQEMQLKEAKHIA EDSDRKYEEVARKLVILEGELERSE ERAEVAESRARQLEEELRTMDQALK SLMASEEEYSTKEDKYEEEIKLLEE KLKEAETRAEFAERSVAKLEKTIDD LEETLASAKEENVEIHQTLDQTLLE LNNL

Gene Information

• Gene Name: TPM2 tropomyosin 2 (beta) [ Homo sapiens ]
• Official Symbol: TPM2
• Synonyms: TPM2; tropomyosin 2 (beta); AMCD1, arthrogryposis multiplex congenital, distal, type 1; tropomyosin beta chain; DA1
• Gene ID: 7169
• mRNA Refseq: NM_003289
• Protein Refseq: NP_003280
• MIM: 190990
• Uniprot ID: P07951
• Chromosome Location: 9p13
• Pathway: Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem
• Function: actin binding; structural constituent of muscle