Recombinant Human TPR, His-tagged

• Cat.No.: TPR-30424TH
• Product Overview: Recombinant fragment, corresponding to amino acids 69-668 of Human TPR with N terminal His tag. MWt: 69 kDa

Specification

• Description: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5 end of this gene with several different kinase genes occur in some neoplasias.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Highest in testis, lung, thymus, spleen and brain, lower levels in heart, liver and kidney.
• Form: Lyophilised:Reconstitute with 103 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: VNETRECQSLRLELEKLNNQLKALT EKNKELEIAQDRNIA IQSQFTRTKEELEAEKRDLIRTNER LSQELEYLTEDVK RLNEKLKESNTTKGELQLKLDELQA SDVSVKYREKRLE QEKELLHSQNTWLNTELKTKTDELL ALGREKGNEILELKC NLENKKEEVSRLEEQMNGLKTSNEH LQKHVEDLLTKLK EAKEQQASMEEKFHNELNAHIKLSN LYKSAADDSEAKS NELTRAVEELHKLLKEAGEANKAIQ DHLLEVEQSKDQMEK EMLEKIGRLEKELENANDLLSATKR KGAILSEEELAAM SPTAAAVAKIVKPGMKLTELYNAYV ETQDQLLLEKLEN KRINKYLDEIVKEVEAKAPILKRQR EEYERAQKAVASLSV KLEQAMKEIQRLQEDTDKANKQSSV LERDNRRMEIQVK DLSQQIRVLLMELEEARGNHVIRDE EVSSADISSSSEV ISQHLVSYRNIEELQQQNQRLLVAL RELGETREREEQETTSSKITELQLK LESALTELEQLRKSRQHQMQLVDSI VRQ RDMYRILLSQTTGVAIPLHASSLDD VSLASTPKRPSTS QTVSTPAPVPVIESTEAIEA(Amino acid sequence (Sequence determined by 5 Sequencing))

Gene Information

• Gene Name: TPR translocated promoter region (to activated MET oncogene) [ Homo sapiens ]
• Official Symbol: TPR
• Synonyms: TPR; translocated promoter region (to activated MET oncogene); nucleoprotein TPR
• Gene ID: 7175
• mRNA Refseq: NM_003292
• Protein Refseq: NP_003283
• MIM: 189940
• Uniprot ID: P12270
• Chromosome Location: 1q25
• Pathway: Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystem; Formation and Maturation of mRNA Transcript, organism-specific biosystem; Gene Expression, organism-specific biosystem; Glucose transport, organism-specific biosystem; HIV Infection, organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein binding; serine-tRNA ligase activity