Recombinant Human TRAF2, His-tagged

• Cat.No.: TRAF2-31601TH
• Product Overview: Recombinant full length Human TRAF2 with N-terminal His tag expressed by Baculovirus in Sf9 insect cells, MWt 59 kDa.

Specification

• Description: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
• Conjugation: HIS
• Form: Liquid
• Storage buffer: Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 2mM DTT, 0.1mM PMSF, pH 7.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the TNF receptor-associated factor family. A subfamily.Contains 1 MATH domain.Contains 1 RING-type zinc finger.Contains 2 TRAF-type zinc fingers.

Gene Information

• Gene Name: TRAF2 TNF receptor-associated factor 2 [ Homo sapiens ]
• Official Symbol: TRAF2
• Synonyms: TRAF2; TNF receptor-associated factor 2; TRAP3
• Gene ID: 7186
• mRNA Refseq: NM_021138
• Protein Refseq: NP_066961
• MIM: 601895
• Uniprot ID: Q12933
• Chromosome Location: 9q34
• Pathway: Activation of Pro-Caspase 8, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem
• Function: CD40 receptor binding; enzyme binding; identical protein binding; ligase activity; metal ion binding

Reviews

11/11/2022

Efficient peptide synthesis, accelerates our peptide-focused projects.

10/07/2021

Reliable antibody validation, vital for our experimental success.

02/21/2021

Accurate mass spectrometry analysis, critical for our proteomics studies.

Q&As

What are the mechanisms by which TRAF2 modulates stress response pathways in cells?

TRAF2 modulates cellular stress response pathways, helping cells adapt to environmental and internal stressors.

What role does TRAF2 play in regulating apoptosis and cell survival signals?

TRAF2 plays a crucial role in cell survival and apoptosis, balancing signals to determine cell fate.

How does TRAF2 mediate signal transduction in the TNF receptor pathway, particularly in inflammatory responses?

TRAF2 is a key mediator in the TNF receptor signaling pathway, regulating inflammatory responses and cytokine production.

How does TRAF2 influence the development and progression of cancer, especially in terms of tumor cell survival and proliferation?

TRAF2 affects cancer progression, influencing tumor cell survival, proliferation, and resistance to apoptosis.

How does TRAF2 contribute to immune system regulation, particularly in adaptive immune responses?

TRAF2 is involved in immune system regulation, affecting both innate and adaptive immune responses.

How do alterations in TRAF2 expression or function affect the body's response to infections and pathogens?

Changes in TRAF2 function impact the body's ability to respond to infections, affecting immune defense mechanisms.

What is the impact of TRAF2 dysregulation on the pathogenesis of autoimmune diseases?

Dysregulation of TRAF2 can contribute to the development of autoimmune diseases by altering immune responses.